THINC-it 工具：随时间推移的变化敏感性。

The THINC-it tool: temporal sensitivity to change over time.

机构信息

Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.

Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

BMC Psychiatry. 2024 Oct 29;24(1):749. doi: 10.1186/s12888-024-06170-8.

DOI:10.1186/s12888-024-06170-8

PMID:39472833

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11520385/

Abstract

INTRODUCTION

Cognitive dysfunction is believed to be among the core features of Bipolar Depression(BD-D). However, its evaluation and available treatments are limited. Here, we conducted a longitudinal follow-up clinical trial using the THINC-it tool to evaluate temporal sensitivity to change over time in cognitive function among patients with bipolar depression from a Chinese cohort. It is helpful to verify whether the scale can continuously and reliably measure cognitive function in different time points and reduce the measurement error caused by time factors. Hope our findings could provide insights into the significance of the THINC-it tool as an iterative clinical cognitive evaluation tool.

METHODS

A total of 120 patients with bipolar depression(40 males and 80 females, respectively) alongside 100 healthy controls(23 males and 77 females, respectively) were recruited in the study. All participants were interviewed for 8 weeks, using the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Young Mania Rating Scale(YMRS). The primary dependent measure was the previously validated THINC-it tool, followed by psychometric analysis.

RESULTS

Repeated measures of the THINC-it tool at baseline, one-week, and eight-week periods were conducted after controlling for age, gender, and education effects. Results from the general linear model revealed no significant time differences in variances(P > 0.05). Similarly, adjusting for confounding factors (age, gender, education, and HAMD-17 scores), results from the longitudinal analysis showed that there were no significant differences in cognitive impairment over time(P > 0.05). However, we found significant differences between BD-D and Healthy Control(HC) groups with regards to Spotter, Codebreaker, Trails, Perceived Deficits Questionnaire for Depression-5-items(PDQ-5-D), and THINC-it Total composite(P < 0.05), but not in Symbol Check (p = 0.191).

CONCLUSION

These findings indicate that the THINC-it tool effectively detects sensitivity to change in groups and maintains stability at times, indicating that it is a feasible and reliable instrument for evaluating cognitive dysfunction in Chinese patients with bipolar depression.

摘要

简介

认知功能障碍被认为是双相抑郁（BD-D）的核心特征之一。然而，其评估和现有治疗方法有限。在这里，我们使用 THINC-it 工具对来自中国队列的双相抑郁患者进行了纵向随访临床试验，以评估认知功能随时间的变化的时间敏感性。这有助于验证该量表是否可以在不同时间点持续可靠地测量认知功能，并减少时间因素引起的测量误差。希望我们的发现可以深入了解 THINC-it 工具作为迭代临床认知评估工具的意义。

方法

本研究共纳入 120 例双相抑郁患者（男 40 例，女 80 例）和 100 例健康对照者（男 23 例，女 77 例）。所有参与者均接受 17 项汉密尔顿抑郁量表（HAMD-17）和 Young 躁狂量表（YMRS）的 8 周访谈。主要的因变量是之前验证过的 THINC-it 工具，然后进行心理测量学分析。

结果

在控制年龄、性别和教育效果后，在基线、一周和八周时对 THINC-it 工具进行了重复测量。一般线性模型的结果显示，方差在时间上没有显著差异（P>0.05）。同样，在调整混杂因素（年龄、性别、教育和 HAMD-17 评分）后，纵向分析的结果显示，认知障碍在时间上没有显著差异（P>0.05）。然而，我们发现 BD-D 组和健康对照组（HC）在 Spotter、Codebreaker、Trails、Perceived Deficits Questionnaire for Depression-5-items（PDQ-5-D）和 THINC-it 总综合评分方面存在显著差异（P<0.05），但在 Symbol Check 方面没有差异（p=0.191）。