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腺样体后鼻孔息肉中的蛋白酶-抗蛋白酶系统。I. 前激活剂存在的证据。

A protease-antiprotease system in antrochoanal polyp. I. Evidence for the existence of proactivator.

作者信息

Kosugi T, Morimitsu T, Matsuo O, Mihara H

出版信息

Arch Otorhinolaryngol. 1979;225(2):97-102. doi: 10.1007/BF00455209.

DOI:10.1007/BF00455209
PMID:394730
Abstract

Tissue extract of antrochoanal polyps showed a faint lysis area on standard fibrin plates, but streptokinase (SK)-added tissue extract showed a large lysis area. No fibrinolytic activity was observed on plasminogen-free fibrin plates. It is concluded, therefore, that the fibrinolytic activity observed after SK addition is indicative of the existence of SK-responsive protein proactivator. The tissue extract did not contain plasminogen or antiprotease against trypsin or papain. It was stable at neutral pH at 37 degrees C and stable at acid pH at 70 degrees C. The role of proactivator is discussed in relation to the growth or enlargement of antrochoanal polyps.

摘要

上颌窦后鼻孔息肉的组织提取物在标准纤维蛋白平板上显示出微弱的溶解区域，但添加链激酶（SK）的组织提取物显示出较大的溶解区域。在无纤溶酶原的纤维蛋白平板上未观察到纤维蛋白溶解活性。因此得出结论，添加SK后观察到的纤维蛋白溶解活性表明存在SK反应性蛋白前激活剂。该组织提取物不含纤溶酶原或针对胰蛋白酶或木瓜蛋白酶的抗蛋白酶。它在37℃中性pH条件下稳定，在70℃酸性pH条件下稳定。讨论了前激活剂在上颌窦后鼻孔息肉生长或增大方面的作用。

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Arch Otorhinolaryngol. 1979;225(2):97-102. doi: 10.1007/BF00455209.
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引用本文的文献

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本文引用的文献

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GEL FILTRATION OF FIBRINOLYTIC COMPONENTS OF BLOOD PLASMA IN MAN AND RABBIT.人及兔血浆中纤溶成分的凝胶过滤
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Studies on the fibrinolysis in tumor bearing mice. 3. Demonstration of the plasminogen activator in Ehrlich ascites tumor cells.荷瘤小鼠纤维蛋白溶解的研究。3. 艾氏腹水癌细胞中纤溶酶原激活物的证明。
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[A small molecule proactivator of plasminogen derived from the macromolecule one by lysine-sepharose chromatography (author's transl)].一种通过赖氨酸-琼脂糖层析从大分子纤溶酶原衍生而来的小分子纤溶酶原激活剂（作者译）
Nihon Seirigaku Zasshi. 1974;36(5):176-85.