Ozcan Cengiz, Ismi Onur, Kara Tuba, Polat Gurbuz, Erdogan Osman, Balci Fidanci Senay, Vayisoglu Yusuf, Gorur Kemal
Mersin University, Department of Otorhinolaryngology, Mersin, Turkey.
Mersin University Department of Otorhinolaryngology, Mersin, Turkey.
Medeni Med J. 2020;35(1):40-46. doi: 10.5222/MMJ.2020.78889. Epub 2020 Feb 28.
Antrochoanal polyp (ACP) is a benign soft tissue lesion arising from the inner wall of the maxillary sinus that extends into the nasal cavity and choana. Although it was first explained by Killian in 1906, the underlying pathogenesis has not been yet fully understood. Neurotrophins have been demonstrated to have a possible role in the pathogenesis of allergic rhinitis, idiopathic rhinitis and nasal polyps. To date any study has not investigated the function of neuronal inflammation and neurotrophins in the development of ACP. The objective of this study was to investigate the possible effect of neurotrophin-3 (NT-3) in ACP pathogenesis.
Twenty adult patients with ACP who underwent endoscopic sinus surgery in our department were included in the study group. The control group included 15 patients with concha bullosa of middle concha who underwent lateral excisional surgery. Nasal tissue NT-3 staining scores were evaluated using immunohistochemical methods. Blood NT-3 levels of both groups were evaluated by enzyme-linked immunosorbent assay (ELISA).
There were no statistically significant differences between these two groups regarding tissue NT-3 staining scores (p=0.843) and blood NT-3 levels (p=0.463). In addition, no statistically significant correlation has been observed between tissue NT-3 staining scores and blood NT-3 levels in both ACP (p=0.578) and control (p=0.359) group patients.
NT-3-related neuronal inflammation does not seem to have any role in ACP pathogenesis.
上颌窦后鼻孔息肉（ACP）是一种起源于上颌窦内壁并延伸至鼻腔和后鼻孔的良性软组织病变。尽管1906年基利安首次对其进行了解释，但其潜在发病机制尚未完全明确。神经营养因子已被证明在变应性鼻炎、特发性鼻炎和鼻息肉的发病机制中可能发挥作用。迄今为止，尚无研究探讨神经元炎症和神经营养因子在ACP发生发展中的作用。本研究的目的是探讨神经营养因子-3（NT-3）在ACP发病机制中的可能作用。
研究组纳入20例在我科接受鼻内镜鼻窦手术的成年ACP患者。对照组包括15例行中鼻甲泡状鼻甲外侧切除术的患者。采用免疫组织化学方法评估鼻组织NT-3染色评分。两组患者的血液NT-3水平采用酶联免疫吸附测定（ELISA）进行评估。
两组在组织NT-3染色评分（p=0.843）和血液NT-3水平（p=0.463）方面无统计学显著差异。此外，在ACP组（p=0.578）和对照组（p=0.359）患者中，均未观察到组织NT-3染色评分与血液NT-3水平之间存在统计学显著相关性。
NT-3相关的神经元炎症似乎在ACP发病机制中不起任何作用。
