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用于多功能治疗应用的磁性α-FeO/CuO/CuFeO纳米复合材料的一锅法合成与表征

One-Pot Synthesis and Characterization of Magnetic α-FeO/CuO/CuFeO Nanocomposite for Multifunctional Therapeutic Applications.

作者信息

Sahara Fahmida Akter, Sultana Mst Sabiha, Amin Md Khairul, Shamim Al Mamun Muhammad, Dhar Palash Kumar, Dutta Sagar Kumar

机构信息

Chemistry Discipline, Khulna University, Khulna, 9208, Bangladesh.

Agrotechnology Discipline, Khulna University, Khulna, 9208, Bangladesh.

出版信息

ChemistryOpen. 2025 Feb;14(2):e202400277. doi: 10.1002/open.202400277. Epub 2024 Oct 30.

DOI:10.1002/open.202400277
PMID:39473328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11808263/
Abstract

This study demonstrates a novel nanostructured drug delivery system utilizing α-FeO/CuO/CuFeO ternary nanocomposite for effective drug transport in sick tissues. Centella Asiatica plant extract was employed to synthesize the FeO/CuO/CuFeO nanocomposite via sol-gel auto combustion technique. The structural and morphological characteristics of the nanocomposite were investigated by XRD, FT-IR, SEM, EDX, and VSM for magnetic properties. The XRD analysis demonstrates the successful synthesis of FeO/CuO/CuFeO nanocomposite with an average crystallite size of 18.393 nm. The antioxidant and antifungal capabilities of this nanocomposite were assessed for its biological activity. A notable inhibitory zone was observed when tested against the Alternaria spp. and Bipolaris sorokiniana fungi. An IC value of 109.88 μg/ml was found in the DPPH test, indicating that the nanocomposite exhibited remarkable antioxidant characteristics. Subsequently, metronidazole was encapsulated with a success rate of 55.53 % at pH 1.2, while at pH 7.4 it gained 57.83 %. The drug release of nanocomposite at pH 1.2 after 330 min was 43.41 % and at pH 7.4 after 300 min it was 52.3 %. The results indicate its potential as an excellent candidate for drug delivery. Furthermore, pH was found to be an effective catalyst in the drug loading and release processes.

摘要

本研究展示了一种新型的纳米结构药物递送系统，该系统利用α-FeO/CuO/CuFeO三元纳米复合材料在患病组织中实现有效的药物运输。采用积雪草植物提取物通过溶胶-凝胶自燃技术合成FeO/CuO/CuFeO纳米复合材料。通过XRD、FT-IR、SEM、EDX和VSM对纳米复合材料的结构和形态特征进行了研究以分析其磁性。XRD分析表明成功合成了平均晶粒尺寸为18.393 nm的FeO/CuO/CuFeO纳米复合材料。评估了该纳米复合材料的抗氧化和抗真菌能力以确定其生物活性。在针对链格孢属和小麦根腐离蠕孢真菌进行测试时观察到显著的抑菌圈。在DPPH测试中发现IC值为109.88 μg/ml，表明该纳米复合材料具有显著的抗氧化特性。随后，甲硝唑在pH 1.2时的包封成功率为55.53 %，而在pH 7.4时为57.83 %。纳米复合材料在pH 1.2下330 min后的药物释放率为43.41 %，在pH 7.4下300 min后的药物释放率为52.3 %。结果表明其作为药物递送的优秀候选者的潜力。此外，发现pH是药物负载和释放过程中的有效催化剂。

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4
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5
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6
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