Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.
J Mater Chem B. 2023 Oct 18;11(40):9597-9629. doi: 10.1039/d3tb01186k.
Polyesters based on polyols have emerged as promising biomaterials for various biomedical applications, such as tissue engineering, drug delivery systems, and regenerative medicine, due to their biocompatibility, biodegradability, and versatile physicochemical properties. This review article provides an overview of the synthesis methods, performance, and biodegradation mechanisms of polyol-based polyesters, highlighting their potential for use in a wide range of biomedical applications. The synthesis techniques, such as simple polycondensation and enzymatic polymerization, allow for the fine-tuning of polyester structure and molecular weight, thereby enabling the tailoring of material properties to specific application requirements. The physicochemical properties of polyol-based polyesters, such as hydrophilicity, crystallinity, and mechanical properties, can be altered by incorporating different polyols. The article highlights the influence of various factors, such as molecular weight, crosslinking density, and degradation medium, on the biodegradation behavior of these materials, and the importance of understanding these factors for controlling degradation rates. Future research directions include the development of novel polyesters with improved properties, optimization of degradation rates, and exploration of advanced processing techniques for fabricating scaffolds and drug delivery systems. Overall, polyol-based polyesters hold significant potential in the field of biomedical applications, paving the way for groundbreaking advancements and innovative solutions that could revolutionize patient care and treatment outcomes.
基于多元醇的聚酯已成为各种生物医学应用（如组织工程、药物传递系统和再生医学）中很有前途的生物材料，因为它们具有生物相容性、可生物降解性和多样化的物理化学性质。本文综述了多元醇基聚酯的合成方法、性能和生物降解机制，强调了它们在广泛的生物医学应用中的潜力。合成技术，如简单的缩聚和酶聚合，允许精细调整聚酯的结构和分子量，从而能够根据特定的应用要求定制材料性能。多元醇基聚酯的物理化学性质，如亲水性、结晶性和机械性能，可以通过引入不同的多元醇来改变。本文强调了各种因素（如分子量、交联密度和降解介质）对这些材料生物降解行为的影响，以及了解这些因素以控制降解速率的重要性。未来的研究方向包括开发具有改进性能的新型聚酯、优化降解速率以及探索用于制造支架和药物传递系统的先进加工技术。总的来说，多元醇基聚酯在生物医学应用领域具有重要的潜力，为突破性进展和创新解决方案铺平了道路，这些进展和解决方案可能会彻底改变患者的护理和治疗效果。
