• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

甲硫氨酸脑啡肽的晶体结构。

Crystal structure of methionine-enkephalin.

作者信息

Mastropaolo D, Camerman A, Camerman N

出版信息

Biochem Biophys Res Commun. 1986 Jan 29;134(2):698-703. doi: 10.1016/s0006-291x(86)80476-4.

DOI:10.1016/s0006-291x(86)80476-4
PMID:3947345
Abstract

The crystal structure of methionine-enkephalin has been determined by X-ray crystallography. There are two independent pentapeptides in the asymmetric unit and both display extended backbone conformations with their side chains arranged alternately below and above the backbone plane. The two molecules form a hydrogen-bonded head-to-tail dimer similar in conformation to one dimeric pair of leucine-enkephalin molecules in a previously reported crystal structure.

摘要

甲硫氨酸脑啡肽的晶体结构已通过X射线晶体学确定。不对称单元中有两个独立的五肽,两者均呈现出伸展的主链构象,其侧链在主链平面的下方和上方交替排列。这两个分子形成了一个氢键连接的头对头二聚体,其构象与先前报道的晶体结构中亮氨酸脑啡肽分子的一个二聚体对相似。

相似文献

1
Crystal structure of methionine-enkephalin.甲硫氨酸脑啡肽的晶体结构。
Biochem Biophys Res Commun. 1986 Jan 29;134(2):698-703. doi: 10.1016/s0006-291x(86)80476-4.
2
Crystal structure of an extended-conformation leucine-enkephalin dimer monohydrate.延伸构象亮氨酸脑啡肽二聚体一水合物的晶体结构
Life Sci. 1987 May 18;40(20):1995-9. doi: 10.1016/0024-3205(87)90289-x.
3
Crystal structure of leucine-enkephalin.亮氨酸脑啡肽的晶体结构。
Nature. 1983;306(5942):447-50. doi: 10.1038/306447a0.
4
The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet.[Met5]脑啡肽和第三种形式的[Leu5]脑啡肽的晶体结构:对一种新型折叠β-片层的观察
Proc Natl Acad Sci U S A. 1986 May;83(10):3272-6. doi: 10.1073/pnas.83.10.3272.
5
Crystal structures of [Met5] and [(4-bromo)Phe4,Met5]enkephalins: formation of a dimeric antiparallel beta-structure.[甲硫氨酸5]和[(4-溴)苯丙氨酸4,甲硫氨酸5]脑啡肽的晶体结构:二聚体反平行β结构的形成
J Biochem. 1987 Feb;101(2):485-90. doi: 10.1093/oxfordjournals.jbchem.a121934.
6
X-ray diffraction studies of enkephalins. Crystal structure of [(4'-bromo) Phe4,Leu5]enkephalin.脑啡肽的X射线衍射研究。[(4'-溴)苯丙氨酸4,亮氨酸5]脑啡肽的晶体结构。
Biochem J. 1984 Mar 15;218(3):677-89. doi: 10.1042/bj2180677.
7
Molecular-dynamics simulations of [Met5]- and [D-Ala2,Met5]-enkephalins. Biological implication of monomeric folded and dimeric unfolded conformations.[Met5]-脑啡肽和[D-Ala2,Met5]-脑啡肽的分子动力学模拟。单体折叠构象和二聚体未折叠构象的生物学意义。
Biochem J. 1988 Oct 15;255(2):621-8.
8
Enkephalin: conformational analysis by means of empirical energy calculations.脑啡肽:通过经验能量计算进行构象分析。
Proc Natl Acad Sci U S A. 1977 Feb;74(2):414-8. doi: 10.1073/pnas.74.2.414.
9
Solution and membrane structure of enkephalins as studied by infrared spectroscopy.
Biochem Biophys Res Commun. 1988 Jan 15;150(1):245-51. doi: 10.1016/0006-291x(88)90512-8.
10
Substrate access to the active sites in aminopeptidase T, a representative of a new metallopeptidase clan.底物进入氨肽酶T(一种新的金属肽酶家族的代表)活性位点的情况。
J Mol Biol. 2005 Nov 25;354(2):403-12. doi: 10.1016/j.jmb.2005.09.042. Epub 2005 Sep 30.

引用本文的文献

1
Conformational stability and three-dimensional model of the delta-opioid pharmacophore for the extended antiparallel dimer structure of Met-enkephalin in water.甲硫氨酸脑啡肽在水中延伸反平行二聚体结构的δ-阿片受体药效基团的构象稳定性和三维模型。
J Mol Model. 2007 Jan;13(1):171-7. doi: 10.1007/s00894-006-0139-6. Epub 2006 Sep 14.
2
A multidimensional 1H NMR investigation of the conformation of methionine-enkephalin in fast-tumbling bicelles.快速翻滚双分子层中蛋氨酸脑啡肽构象的多维¹H NMR研究。
Biophys J. 2004 Mar;86(3):1587-600. doi: 10.1016/S0006-3495(04)74226-5.
3
Molecular-dynamics simulations of [Met5]- and [D-Ala2,Met5]-enkephalins. Biological implication of monomeric folded and dimeric unfolded conformations.
[Met5]-脑啡肽和[D-Ala2,Met5]-脑啡肽的分子动力学模拟。单体折叠构象和二聚体未折叠构象的生物学意义。
Biochem J. 1988 Oct 15;255(2):621-8.
4
Conformational characteristics of receptor-selective opioid peptides. 1H n.m.r. and c.d. spectroscopic studies of delta-kephalin and [Val4]morphiceptin.受体选择性阿片肽的构象特征。δ-脑啡肽和[缬氨酸4]吗啡肽的1H核磁共振和圆二色光谱研究。
Biochem J. 1988 Apr 15;251(2):581-8. doi: 10.1042/bj2510581.
5
The neuropeptide head activator loses its biological acitivity by dimerization.神经肽头部激活剂通过二聚化失去其生物活性。
EMBO J. 1986 Aug;5(8):1825-9. doi: 10.1002/j.1460-2075.1986.tb04433.x.
6
Characterization of low-energy conformational domains for Met-enkephalin.甲硫氨酸脑啡肽低能量构象域的表征
J Comput Aided Mol Des. 1992 Apr;6(2):175-90. doi: 10.1007/BF00129427.