Fei Yifan, Ding Yifei
School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Front Cell Neurosci. 2024 Oct 15;18:1475934. doi: 10.3389/fncel.2024.1475934. eCollection 2024.
Ferroptosis represents an iron and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence strongly suggests the involvement of ferroptosis in various neurodegenerative diseases (NDs), particularly Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), among others. The treatment of ferroptosis poses both opportunities and challenges in the context of ND. This review provides a comprehensive overview of characteristic features, induction and inhibition of ferroptosis, highlighting the ferroptosis inhibitor and the underlying mechanisms responsible for its occurrence. Moreover, the review explores how these mechanisms contribute to the pathogenesis and progression of major neurodegenerative disorders. Additionally, it presents novel insights into the role of ferroptosis in ND and summarizes recent advancements in the development of therapeutic approaches targeting ferroptosis. These insights and advancements hold potential to guide future strategies aimed at effectively managing these debilitating medical conditions.
铁死亡是一种由铁和脂质过氧化（LPO）介导的程序性细胞死亡（RCD）形式。最近的证据有力地表明，铁死亡参与了各种神经退行性疾病（NDs），特别是阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）、多发性硬化症（MS）和肌萎缩侧索硬化症（ALS）等。在神经退行性疾病的背景下，铁死亡的治疗既带来了机遇，也带来了挑战。本综述全面概述了铁死亡的特征、诱导和抑制，重点介绍了铁死亡抑制剂及其发生的潜在机制。此外，该综述探讨了这些机制如何导致主要神经退行性疾病的发病机制和进展。此外，它还对铁死亡在神经退行性疾病中的作用提出了新的见解，并总结了靶向铁死亡的治疗方法开发的最新进展。这些见解和进展有可能指导未来旨在有效管理这些使人衰弱的疾病的策略。
