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一名接受抗肿瘤坏死因子α(TNFα)治疗的川崎病患者的潜伏性结核感染治疗

Treatment of Latent Tuberculosis Infection in a Kawasaki Disease Patient Receiving Anti-Tumor Necrosis Factor Alpha (TNFα) Therapy.

作者信息

Yokoyama Koji, Yakuo Toshinari, Mamada Mitsukazu

机构信息

Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, JPN.

出版信息

Cureus. 2024 Sep 28;16(9):e70407. doi: 10.7759/cureus.70407. eCollection 2024 Sep.

Abstract

Kawasaki disease (KD) is a common vasculitis syndrome that mainly affects children. Latent tuberculosis infection (LTBI) is a tuberculosis (TB) infection without signs or symptoms. Here, we report the case of a boy who traveled from abroad, was diagnosed with KD at our hospital, and underwent multidisciplinary treatment, including anti-TNFα therapy. Subsequently, the patient was found to have LTBI and was administered anti-TB treatment. To the best of our knowledge, this is the first reported case of LTBI in a KD patient receiving immunosuppressive therapy containing anti-TNFα.

摘要

川崎病(KD)是一种主要影响儿童的常见血管炎综合征。潜伏性结核感染(LTBI)是一种没有体征或症状的结核(TB)感染。在此,我们报告一例从国外前来就诊的男孩病例,该男孩在我院被诊断为川崎病,并接受了包括抗TNFα治疗在内的多学科治疗。随后,该患者被发现患有潜伏性结核感染,并接受了抗结核治疗。据我们所知,这是首例报道的在接受含抗TNFα免疫抑制治疗的川崎病患者中发生潜伏性结核感染的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1699/11519388/58457de8a4cb/cureus-0016-00000070407-i01.jpg

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