Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Samsun University, Samsun, Turkiye.
Vocational School of Technical Sciences, Samsun University, Samsun, Turkiye.
Turk J Med Sci. 2024 Sep 8;54(5):1092-1101. doi: 10.55730/1300-0144.5888. eCollection 2024.
BACKGROUND/AIM: YO-AlO-SiO (YAS) glass microspheres are currently used in radioembolization treatment. However, abscess formation can occur following this treatment. This study aims to endow YAS glass microspheres with antibacterial properties to address the abscesses forming in patients after radioembolization treatment.
In this study, undoped YAS glass microspheres and those doped with antibacterial agents zinc (Zn) and/or copper (Cu) were successfully fabricated using a sol-gel derived method.
After heat treatment, the microspheres exhibited an amorphous structure. Additionally, the incorporation of Zn and/or Cu dopants did not alter the patterns observed in the X-ray diffraction analysis. Fourier transform infrared spectroscopy analysis detected Si-O-Si, Al-O-Al, and Y-O band vibrations within the structure. The presence of Zn and Cu dopants was confirmed through X-ray photoelectron spectroscopy analysis. Scanning electron microscopy revealed that all samples possessed a regular microsphere morphology, with average particle sizes ranging from 6 to 50 μm. These average particle sizes were further confirmed using a mastersizer.
The antibacterial agent-doped YAS glass microspheres show promise in combating infections that occur following radioembolization treatment.
背景/目的：YO-AlO-SiO（YAS）玻璃微球目前用于放射性栓塞治疗。然而，这种治疗后可能会形成脓肿。本研究旨在赋予 YAS 玻璃微球抗菌性能，以解决放射性栓塞治疗后患者出现脓肿的问题。
本研究采用溶胶-凝胶法成功制备了未掺杂和掺杂抗菌剂锌（Zn）和/或铜（Cu）的 YAS 玻璃微球。
经过热处理后，微球呈现出非晶态结构。此外，Zn 和/或 Cu 掺杂剂的掺入并未改变 X 射线衍射分析中观察到的图案。傅里叶变换红外光谱分析检测到结构内的 Si-O-Si、Al-O-Al 和 Y-O 带振动。X 射线光电子能谱分析证实了 Zn 和 Cu 掺杂剂的存在。扫描电子显微镜显示，所有样品均具有规则的微球形态，平均粒径范围为 6-50μm。使用 mastersizer 进一步证实了这些平均粒径。
抗菌剂掺杂的 YAS 玻璃微球有望用于治疗放射性栓塞治疗后发生的感染。
