Department of Material Science and Nanotechnology, Deenbandhu Chhotu Ram University of Science and Technology, Murthal 131039, India.
J Nanosci Nanotechnol. 2020 Apr 1;20(4):2465-2472. doi: 10.1166/jnn.2020.17336.
Bioactive glasses are inorganic biomaterials that have been used successfully in bone tissue engineering and in dentistry as filling materials. But due to poorer mechanical strength the bioactive glasses have limited application in load-bearing positions. If efforts are made to increase material strength, their bioactivity gets decrease. To comprehend the optimal toning between biological and mechanical properties, we aim to develop the new nano bioactive glass using simple sol-gel method having a composition of 50%SiO2-40%CaO-5%P2O5-2%ZnO-2%MgO-1%SrO (mol%) with three different bivalent metal ions (Zn, Mg and Sr). The structural morphology, crystallinity, physical and chemical behavior of the prepared bioglass ceramics were analyzed through XRD, N2-adsorption measurements, FTIR, FESEM with EDS and HR-TEM. The bioactivity of the sample was analyzed in Dulbecco's modified eagle's medium solution for ten days. The synthesized nano bioglass-ceramic shows the apatite layer formation which was confirmed through XRD and FTIR and show anti-bacterial properties for the four well-known pathogens/microorganism and .
生物活性玻璃是一种无机生物材料，已成功应用于骨组织工程和牙科作为填充材料。但是由于机械强度较差，生物活性玻璃在承重部位的应用受到限制。如果要提高材料强度，其生物活性就会降低。为了理解生物和机械性能之间的最佳协调，我们旨在使用简单的溶胶-凝胶法开发具有 50%SiO2-40%CaO-5%P2O5-2%ZnO-2%MgO-1%SrO（摩尔%）组成的新型纳米生物活性玻璃，其中含有三种不同的二价金属离子（Zn、Mg 和 Sr）。通过 XRD、N2-吸附测量、FTIR、FESEM 与 EDS 和 HR-TEM 分析了所制备的生物玻璃陶瓷的结构形态、结晶度、物理化学行为。通过在杜氏改良鹰培养基溶液中分析样品的生物活性达十天。通过 XRD 和 FTIR 证实了合成的纳米生物玻璃陶瓷形成了磷灰石层，并对四种知名的病原体/微生物表现出抗菌性能。
