Erbe E M, Day D E
Ceramic Engineering Department, University of Missouri-Rolla 65401.
J Biomed Mater Res. 1993 Oct;27(10):1301-8. doi: 10.1002/jbm.820271010.
Microspheres made from Y2O3-Al2O3-SiO2 (YAS) glasses, which contain radioactive Y-90, are currently being used to treat liver cancer in humans, where their chemical durability is of prime importance. In deionized water or saline at 37 degrees C, the weight percent Yttrium (Y) dissolved from eight different YAS glasses ranged from only 0.02-0.13% of the total Y present and their dissolution rate was barely measurable, < or = 1.0 x 10(-9) g/cm2-min. The most chemically durable YAS glass was 17Y2O3-19Al2O3-64SiO2, mol%. The small amount of Y released from microspheres, 25-35 microns diameter, of this glass after corrosion in saline or deionized water at 37 degrees C was essentially the same as for bulk glass samples. Based on their excellent chemical durability, it is concluded that YAS glass microspheres are suitable for in vivo use.
由含有放射性钇 - 90的Y2O3 - Al2O3 - SiO2（YAS）玻璃制成的微球目前正用于治疗人类肝癌，其化学耐久性至关重要。在37摄氏度的去离子水或盐水中，从八种不同的YAS玻璃中溶解的钇（Y）重量百分比仅占总Y的0.02 - 0.13%，其溶解速率几乎无法测量，≤1.0×10（-9）g/cm2 - 分钟。化学耐久性最强的YAS玻璃是17Y2O3 - 19Al2O3 - 64SiO2，摩尔百分比。这种玻璃制成的直径为25 - 35微米的微球在37摄氏度的盐水或去离子水中腐蚀后释放的少量Y与块状玻璃样品基本相同。基于其优异的化学耐久性，得出YAS玻璃微球适用于体内使用的结论。
