Xu Ming, Zhang Lingyun, Xu Dong, Shi Wenrui, Zhang Weiguo
Department of Cardiology, The People's Hospital of Suzhou New District, Suzhou City, China.
Suzhou Medical College of Soochow University, Suzhou City, China.
Front Cardiovasc Med. 2024 Oct 15;11:1485538. doi: 10.3389/fcvm.2024.1485538. eCollection 2024.
Coronary heart disease (CHD) is one of the leading causes of mortality. The current study aims to assess the association between C-reactive protein-triglyceride glucose index (CTI) and the risk of prevalent CHD and to evaluate the usefulness of CTI to refine the identification of prevalent CHD.
19,451 subjects from the National Health and Nutrition Examination Survey 1999-2010 were enrolled. CHD was ascertained according to the questionnaire.
The prevalent of CHD was 6.23%. After adjusting for conventional cardiovascular risk factors, each SD increase of CTI could cast a 1.357 times risk of CHD. In quartile analysis, the top quartile had a 1.807 times risk of CHD than the bottom quartile. Smooth curving fitting displayed that the association was linear in the entire range of CTI. Subgroup analysis revealed that the association was robust among several common subpopulations but stronger in subjects aged <60. Finally, both ROC and reclassification analysis demonstrated a significant improvement in identifying CHD when introducing CTI to the Framingham risk score.
CTI has a positive, linear, and robust association with prevalent CHD in the general American population, and CTI may help to improve the detection of prevalent CHD in the general population.
冠心病（CHD）是主要的死亡原因之一。本研究旨在评估C反应蛋白-甘油三酯葡萄糖指数（CTI）与冠心病患病率之间的关联，并评估CTI在优化冠心病患病率识别方面的效用。
纳入了1999 - 2010年美国国家健康与营养检查调查中的19451名受试者。根据问卷确定冠心病情况。
冠心病患病率为6.23%。在调整传统心血管危险因素后，CTI每增加一个标准差，冠心病风险可增加1.357倍。在四分位数分析中，最高四分位数的冠心病风险是最低四分位数的1.807倍。平滑曲线拟合显示，在整个CTI范围内，这种关联呈线性。亚组分析显示，这种关联在几个常见亚组中都很显著，但在年龄<60岁的受试者中更强。最后，受试者工作特征曲线（ROC）分析和重新分类分析均表明，将CTI引入弗明汉风险评分时，在识别冠心病方面有显著改善。
在美国普通人群中，CTI与冠心病患病率呈正相关、线性相关且相关性较强，CTI可能有助于提高普通人群中冠心病患病率的检测。
