Cheng Ningyi, Ma Zhicheng, Chen Yukun, Jin Lei, Chen Liangwan
Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Fujian Provincial Center for Cardiovascular Medicine, Fuzhou, 350001, China.
Sci Rep. 2025 Jul 21;15(1):26363. doi: 10.1038/s41598-025-08389-1.
The C-reactive protein(CRP)-triglyceride glucose index (CTI) is a new composite biomarker used to assess inflammation and insulin resistance(IR) severity. Heart failure (HF) poses a substantial epidemiological threat with increasing incidence and mortality worldwide. However, the relationship between CTI and HF has not been extensively investigated. Using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2001-2010, 21,974 participants ≥ 20 years were included. HF diagnosis was based on self-reported medical history. Multivariable logistic regression adjusted for demographic, lifestyle, and clinical covariates. Smooth curve fitting analyzed dose-response relationships, while subgroup analyses explored effect heterogeneity. The research cohort comprised 21,974 individuals (631 HF cases, 21,343 non-HF). HF patients exhibited significantly higher CTI levels (p < 0.001), and a positive correlation with HF prevalence was observed (p < 0.001). Consistent positive associations were maintained across subgroups, with no significant interactions detected. Logistic regression analysis demonstrated adjusted ORs for HF per 1-unit CTI increase of 1.492 (model 1, unadjusted) and 1.279 (model 3, fully adjusted). Quartile analysis revealed a progressive increase in prevalent HF with higher CTI levels, and model 3 confirmed a nonlinear dose-response relationship (p < 0.001) with a threshold at 11.657. CTI is positively associated with the presence of HF in US adults, suggesting its potential as a biomarker for HF prevention and treatment strategies.
C反应蛋白（CRP）-甘油三酯葡萄糖指数（CTI）是一种用于评估炎症和胰岛素抵抗（IR）严重程度的新型综合生物标志物。心力衰竭（HF）在全球范围内发病率和死亡率不断上升，构成了重大的流行病学威胁。然而，CTI与HF之间的关系尚未得到广泛研究。利用2001年至2010年美国国家健康与营养检查调查（NHANES）的横断面数据，纳入了21974名年龄≥20岁的参与者。HF诊断基于自我报告的病史。对人口统计学、生活方式和临床协变量进行多变量逻辑回归调整。平滑曲线拟合分析剂量反应关系，亚组分析探讨效应异质性。研究队列包括21974人（631例HF病例，21343例非HF）。HF患者的CTI水平显著更高（p<0.001），且观察到与HF患病率呈正相关（p<0.001）。各亚组均保持一致的正相关，未检测到显著的相互作用。逻辑回归分析显示，CTI每增加1个单位，HF的调整后比值比在模型1（未调整）中为1.492，在模型3（完全调整）中为1.279。四分位数分析显示，CTI水平越高，HF患病率逐渐增加，模型3证实了非线性剂量反应关系（p<0.001），阈值为11.657。在美国成年人中，CTI与HF的存在呈正相关，表明其作为HF预防和治疗策略生物标志物的潜力。
