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视网膜缺血继发视网膜色素上皮增殖：病例报告及文献复习

Retinal Pigment Epithelial Proliferation Secondary to Retinal Ischemia: A Case Report and Literature Review.

作者信息

Alnaim Abdullah F, Alsakran Wael A, Alotaibi Hammam A

机构信息

Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Department of Ophthalmology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

出版信息

Case Rep Ophthalmol. 2024 Sep 12;15(1):683-688. doi: 10.1159/000540771. eCollection 2024 Jan-Dec.

DOI:10.1159/000540771
PMID:39474023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11521474/
Abstract

INTRODUCTION

Antiphospholipid syndrome is one of the most common causes of acquired hypercoagulable conditions which is correlated with ocular conditions not least of which is retinal ischemia due to arterial or venous occlusive insults.

CASE PRESENTATION

We describe a case of unilateral retinal ischemia in the setting of combined central retinal artery and vein occlusion with associated proliferation of retinal pigment epithelium. The patient was worked-up for the etiology of her presentation which was found to be antiphospholipid syndrome.

CONCLUSION

Although pigment epithelial proliferation occurs commonly after retinal ischemia, no study has reported complete multimodal imaging of such a pathology or proposed the possible mechanisms explaining such an association.

摘要

引言

抗磷脂综合征是获得性高凝状态最常见的病因之一，与眼部疾病相关，其中尤以动脉或静脉闭塞性损伤导致的视网膜缺血最为突出。

病例报告

我们描述了一例在视网膜中央动脉和静脉联合阻塞及视网膜色素上皮细胞增生情况下发生的单侧视网膜缺血病例。对该患者进行了病因检查，发现病因是抗磷脂综合征。

结论

尽管色素上皮细胞增生在视网膜缺血后很常见，但尚无研究报道过此类病变的完整多模态成像，也未提出解释这种关联的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/1d09880be762/cop-2024-0015-0001-540771_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/97e2d662a48b/cop-2024-0015-0001-540771_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/344418b995b9/cop-2024-0015-0001-540771_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/1d09880be762/cop-2024-0015-0001-540771_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/97e2d662a48b/cop-2024-0015-0001-540771_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/344418b995b9/cop-2024-0015-0001-540771_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1853/11521474/1d09880be762/cop-2024-0015-0001-540771_F03.jpg

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本文引用的文献

1
The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology.视网膜色素上皮细胞在视网膜免疫生物学中对巨噬细胞/小胶质细胞的调节作用
Front Immunol. 2021 Aug 13;12:724601. doi: 10.3389/fimmu.2021.724601. eCollection 2021.
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Antiphospholipid syndrome and antiphospholipid antibody profile in patients with retinal vein occlusion.抗磷脂综合征与视网膜静脉阻塞患者的抗磷脂抗体谱。
Thromb Res. 2020 Jun;190:63-68. doi: 10.1016/j.thromres.2020.04.005. Epub 2020 Apr 12.
3
Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood-retinal barrier in diabetic retinopathy.
小胶质细胞与视网膜色素上皮细胞的相互作用决定了糖尿病性视网膜病变中外血视网膜屏障的完整性。
Glia. 2019 Feb;67(2):321-331. doi: 10.1002/glia.23542. Epub 2018 Nov 16.
4
Diagnosis and Management of the Antiphospholipid Syndrome.抗磷脂综合征的诊断与管理
N Engl J Med. 2018 May 24;378(21):2010-2021. doi: 10.1056/NEJMra1705454.
5
Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation.慢性暴露于肿瘤坏死因子-α可诱导视网膜色素上皮细胞去分化。
J Neuroinflammation. 2018 Mar 16;15(1):85. doi: 10.1186/s12974-018-1106-8.
6
On phagocytes and macular degeneration.关于吞噬细胞和黄斑变性。
Prog Retin Eye Res. 2017 Nov;61:98-128. doi: 10.1016/j.preteyeres.2017.06.002. Epub 2017 Jun 7.
7
Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis.衰老眼中视网膜色素上皮细胞多核化——一种修复损伤和维持内稳态的机制。
Aging Cell. 2016 Jun;15(3):436-45. doi: 10.1111/acel.12447. Epub 2016 Feb 15.
8
Retinal pigment epithelial cell proliferation.视网膜色素上皮细胞增殖
Exp Biol Med (Maywood). 2015 Aug;240(8):1079-86. doi: 10.1177/1535370215587530. Epub 2015 Jun 2.
9
Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells.氧化应激诱导视网膜色素上皮细胞坏死性细胞死亡。
Cell Death Dis. 2013 Dec 12;4(12):e965. doi: 10.1038/cddis.2013.478.
10
Ocular manifestations of the antiphospholipid syndrome.抗磷脂综合征的眼部表现。
Br J Ophthalmol. 2011 Apr;95(4):454-9. doi: 10.1136/bjo.2010.182857. Epub 2010 Aug 7.