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用于肿瘤靶向基因治疗的成像辅助反义寡核苷酸递送

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy.

作者信息

Liao Hanwen, Wang Siyi, Wang Xiaoning, Dai David Zixiang, Zhang Yan, Zhu Chenghong, Li Jinbo

机构信息

State Key Laboratory of Analytical Chemistry for Life Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

Nanjing International School, Xian Lin University City, Qi Xia District, Xue Heng Lu 8, Nanjing 210023, China.

出版信息

Chem Biomed Imaging. 2024 Apr 17;2(5):313-330. doi: 10.1021/cbmi.4c00012. eCollection 2024 May 27.

DOI:10.1021/cbmi.4c00012
PMID:39474120
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11503958/
Abstract

Antisense oligonucleotide (ASO) represents a class of practical tools for targeting undruggable oncogenes with several candidates currently undergoing clinical investigation. The advancement of antisense therapeutics necessitates comprehensive approaches for evaluating their efficacy and improving their accuracy. Molecular imaging techniques offer a qualitative and quantitative means to assess therapeutics at the molecular, cellular, and levels, as well as to elucidate biodistribution and pharmacokinetics. These capabilities play a pivotal role in enhancing therapeutic evaluation and efficiency. This review systematically explores the current landscape of ASO delivery by leveraging a synergistic combination of imaging techniques and delivery vehicles to enhance oligonucleotide distribution and accumulation at tumor sites and thereby optimizing therapeutic outcomes.

摘要

反义寡核苷酸（ASO）是一类用于靶向不可成药致癌基因的实用工具，目前有几种候选药物正在进行临床研究。反义疗法的发展需要综合方法来评估其疗效并提高其准确性。分子成像技术提供了一种定性和定量的手段，可在分子、细胞和组织水平评估治疗效果，以及阐明生物分布和药代动力学。这些能力在加强治疗评估和提高治疗效率方面发挥着关键作用。本综述通过利用成像技术和递送载体的协同组合，系统地探索了ASO递送的现状，以增强寡核苷酸在肿瘤部位的分布和积累，从而优化治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/34c14647810a/im4c00012_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/9da97eafbac2/im4c00012_0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/9ee25f37d5d1/im4c00012_0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/79da31853a31/im4c00012_0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/cc2218219504/im4c00012_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/3178ce1968af/im4c00012_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/34c14647810a/im4c00012_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/9da97eafbac2/im4c00012_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/6879ba67aa6d/im4c00012_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/9ee25f37d5d1/im4c00012_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/6ebcc6459f87/im4c00012_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/79da31853a31/im4c00012_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/b7b10976373d/im4c00012_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/cc2218219504/im4c00012_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/3178ce1968af/im4c00012_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/9a6afa8adbac/im4c00012_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee2/11503958/34c14647810a/im4c00012_0010.jpg

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