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成功重复使用一种病原体吸附仿生装置辅助治疗SARS-CoV-2再感染及随后的不同多重耐药菌感染。

Successful Repeated Use of a Pathogen Adsorbing Biomimetic Device for the Adjunct Treatment of a SARS-CoV-2 Reinfection and Subsequent Infections with Different Multiresistant Bacteria.

作者信息

Okioma Reuben, Soki Khalida, Hay Alexander, Kielstein Jan T

机构信息

Department of Critical Care, The Nairobi Hospital, Nairobi, Kenya.

Department of Nephrology, The Nairobi Hospital, Nairobi, Kenya.

出版信息

Case Rep Nephrol Dial. 2024 Oct 17;14(1):171-177. doi: 10.1159/000541422. eCollection 2024 Jan-Dec.

Abstract

INTRODUCTION

The Seraph 100 Microbind Affinity Filter is a biomimetic adsorbent device that can remove pathogens from the blood.

CASE PRESENTATION

Here, we report the successful use of the Seraph 100 to treat both a SARS-CoV-2 reinfection leading to severe COVID-19 pneumonia as well as subsequent secondary lung infections including Acinetobacter baumannii, Serratia marcescens, and Pseudomonas aeruginosa multidrug-resistant bacteria. To our knowledge, this 46-year-old black male is the first patient in which four treatments with this pathogen adsorber, one for a viral and three for different bacterial infections, have been successfully used.

CONCLUSION

The Seraph 100 can be easily and successfully used in conjunction with standard (anti-infective) treatment.

摘要

简介

Seraph 100微结合亲和过滤器是一种仿生吸附装置,可从血液中清除病原体。

病例报告

在此,我们报告成功使用Seraph 100治疗导致严重COVID-19肺炎的SARS-CoV-2再次感染以及随后的继发性肺部感染,包括鲍曼不动杆菌、粘质沙雷氏菌和多重耐药铜绿假单胞菌。据我们所知,这位46岁的黑人男性是首位成功使用这种病原体吸附器进行四次治疗的患者,其中一次针对病毒感染,三次针对不同的细菌感染。

结论

Seraph 100可轻松且成功地与标准(抗感染)治疗联合使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29df/11521500/16b301eba682/cnd-2024-0014-0001-541422_F01.jpg

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