Zhang Yanju, Du Meiyang, Li Zhouhuiling, Wang Xincheng, Leng Mingxin, Huang Yaping, Li Libin, Zhang Shi, Li Chunjun
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
Int J Endocrinol. 2024 Oct 21;2024:1297584. doi: 10.1155/2024/1297584. eCollection 2024.
Insulin resistance (IR) is an important risk factor for obesity and cardiometabolic diseases, and our previous findings have demonstrated that visceral fat area to skeletal muscle mass ratio (VSR) is significantly and positively associated with the risk of cardiometabolic diseases. Hence, this study aimed to investigate the relationship between VSR and multiorgan IR, provide a new approach to improve body composition, and set the basis for VSR to increase the incidence of cardiometabolic diseases. The study included 398 patients who underwent anthropometric and biochemical measurements, and body composition assessment. Spearman correlation analysis was used to investigate the correlation between VSR and homeostatic model assessment for insulin resistance (HOMA-IR) as well as multiorgan IR, including homeostasis model assessment adiponectin (HOMA-AD), adipose tissue insulin resistance (ADIPO-IR), and hepatic insulin sensitivity (HISI). The new model that incorporated into the present study is made up of easily measured biochemical indicators and is used to predict IR. Logistic regression was used to analyze the odds ratio (OR) of VSR on the risk of multiorgan IR. The predictive value of VSR for HOMA-IR and new model was evaluated using the receiver operating characteristic (ROC) curve. VSR was significantly associated with HOMA-IR, HOMA-AD, ADIPO-IR, 1/HISI, and new model ( < 0.001). With the increase of VSR, the OR increased significantly for HOMA-IR and new model ( < 0.001). Then, multiorgan IR indicators were quantified, compared to the lowest quartile group, and increased VSR exacerbated the risk of IR in the highest quartile ( < 0.001). The area under the curve for predicting IR using VSR for HOMA-IR and new model was 0.88 for men, 0.85 for women and 0.73 for men, 0.76 for women, respectively. There was significant correlation between VSR and multiorgan IR, and the risk of multiorgan IR increased with increasing VSR. Clinical Trial Registry identifier: ChiCTR2100044305.
胰岛素抵抗（IR）是肥胖和心脏代谢疾病的重要危险因素，我们之前的研究结果表明，内脏脂肪面积与骨骼肌质量比（VSR）与心脏代谢疾病风险显著正相关。因此，本研究旨在探讨VSR与多器官IR之间的关系，提供一种改善身体成分的新方法，并为VSR增加心脏代谢疾病发病率奠定基础。该研究纳入了398例接受人体测量、生化检测和身体成分评估的患者。采用Spearman相关性分析来研究VSR与胰岛素抵抗稳态模型评估（HOMA-IR）以及多器官IR之间的相关性，多器官IR包括脂联素稳态模型评估（HOMA-AD）、脂肪组织胰岛素抵抗（ADIPO-IR）和肝脏胰岛素敏感性（HISI）。纳入本研究的新模型由易于测量的生化指标组成，用于预测IR。采用逻辑回归分析VSR对多器官IR风险的比值比（OR）。使用受试者工作特征（ROC）曲线评估VSR对HOMA-IR和新模型的预测价值。VSR与HOMA-IR、HOMA-AD、ADIPO-IR、1/HISI和新模型显著相关（<0.001）。随着VSR的增加，HOMA-IR和新模型的OR显著增加（<0.001）。然后，对多器官IR指标进行量化，与最低四分位数组相比，VSR升高使最高四分位数组的IR风险加剧（<0.001）。使用VSR预测HOMA-IR和新模型的IR的曲线下面积，男性分别为0.88和0.73，女性分别为0.85和0.76。VSR与多器官IR之间存在显著相关性，且多器官IR风险随VSR升高而增加。临床试验注册标识符：ChiCTR2100044305。
