Sharma Manthan, Jorvekar Sachin B, Jala Aishwarya, Pulimamidi Sai Sharanya, Sonone Sagar, Adye Daya Raju, Borkar Roshan M
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Guwahati, Changsari 781101, India.
Environ Health (Wash). 2023 Sep 21;1(5):332-342. doi: 10.1021/envhealth.3c00108. eCollection 2023 Nov 17.
Bisphenol AF has gained popularity as a substitute for bisphenol A in industrial applications, leading to its detection in various biological fluids and raising concerns for public health. While the effects of bisphenol A on lipid metabolism are known, the impact of bisphenol AF on different lipid classes remains understudied. This study aimed to address this gap by conducting an untargeted lipidomics analysis in rats to assess the influence of bisphenol AF on lipid homeostasis. The results of the study revealed significant alterations in lipid profiles in plasma with various lipid classes being affected by bisphenol AF exposure. High-dose exposure to bisphenol AF resulted in specific changes within lipid clusters, including a decrease in the fatty acyl lipid cluster, except for 3,6,9,12,15-octadecapentaenoic acid. Additionally, the compound 9-0-acetyl GTb1(d18:1/18:0) within the gangliosides subclass of the sphingolipids and the sterol lipid clusters was also affected. These findings contribute to a better understanding of how bisphenol AF disrupts lipid metabolism and its associated health effects. This study provides valuable insights into the potential risks posed by bisphenol AF. Further research in this area is warranted to explore the mechanisms underlying the bisphenol AF-induced dysregulation of lipid metabolism and its implications for human health.
双酚AF作为双酚A在工业应用中的替代品而受到欢迎，这导致其在各种生物流体中被检测到，并引发了对公众健康的担忧。虽然双酚A对脂质代谢的影响是已知的，但双酚AF对不同脂质类别的影响仍未得到充分研究。本研究旨在通过对大鼠进行非靶向脂质组学分析来填补这一空白，以评估双酚AF对脂质稳态的影响。研究结果显示，血浆中的脂质谱发生了显著变化，各种脂质类别都受到双酚AF暴露的影响。高剂量暴露于双酚AF导致脂质簇内出现特定变化，包括脂肪酰基脂质簇减少，但3,6,9,12,15-十八碳五烯酸除外。此外，鞘脂类神经节苷脂亚类和甾醇脂质簇中的化合物9-0-乙酰基GTb1(d18:1/18:0)也受到影响。这些发现有助于更好地理解双酚AF如何破坏脂质代谢及其相关的健康影响。本研究为双酚AF带来的潜在风险提供了有价值的见解。该领域需要进一步研究，以探索双酚AF诱导脂质代谢失调的潜在机制及其对人类健康的影响。
