• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1例合并眼部受累的梅毒：1例多发性硬化患者梅毒血清学持续阴性

A Case of Syphilis With Ocular Involvement: Persistent Negative Serology in a Patient With Multiple Sclerosis.

作者信息

Pipitò Luca, Ganci Irene, Cicero Andrea, Medaglia Alice Annalisa, D'Avenia Simona, Mandalà Edoardo, Calà Cinzia, Di Carlo Paola, Cascio Antonio

机构信息

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro," University of Palermo, Palermo, Italy.

Infectious and Tropical Disease Unit, Azienda Ospedaliera Universitaria Policlinico "P. Giaccone,"  Palermo, Italy.

出版信息

Open Forum Infect Dis. 2024 Oct 29;11(10):ofae563. doi: 10.1093/ofid/ofae563. eCollection 2024 Oct.

DOI:10.1093/ofid/ofae563
PMID:39474448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11521249/
Abstract

Diagnostic algorithms for syphilis are based on serology. However, with the advent of immunosuppressive therapies, these algorithms may fail. We report a case of an individual with multiple sclerosis on treatment with ofatumumab and secondary syphilis with visual and auditory systems involvement and persistent negative treponemal and nontreponemal tests.

摘要

梅毒的诊断算法基于血清学。然而，随着免疫抑制疗法的出现，这些算法可能会失效。我们报告了一例患有多发性硬化症的患者，该患者正在接受奥法木单抗治疗，同时患有继发性梅毒，累及视觉和听觉系统，梅毒螺旋体和非梅毒螺旋体检测持续呈阴性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/d4d61090d36a/ofae563f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/1d82e435752c/ofae563f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/f4989b082b70/ofae563f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/d4d61090d36a/ofae563f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/1d82e435752c/ofae563f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/f4989b082b70/ofae563f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc0a/11521249/d4d61090d36a/ofae563f3.jpg

相似文献

1
A Case of Syphilis With Ocular Involvement: Persistent Negative Serology in a Patient With Multiple Sclerosis.1例合并眼部受累的梅毒：1例多发性硬化患者梅毒血清学持续阴性
Open Forum Infect Dis. 2024 Oct 29;11(10):ofae563. doi: 10.1093/ofid/ofae563. eCollection 2024 Oct.
2
Comparison of a combined nontreponemal (VDRL) and treponemal immunoblot to traditional nontreponemal and treponemal assays.联合非梅毒螺旋体（VDRL）和梅毒螺旋体免疫印迹法与传统非梅毒螺旋体和梅毒螺旋体检测方法的比较。
J Clin Lab Anal. 2015 Jan;29(1):68-73. doi: 10.1002/jcla.21730. Epub 2014 Jan 3.
3
Do women with persistently negative nontreponemal test results transmit syphilis during pregnancy?患有持续性非梅毒螺旋体血清学试验阴性结果的女性在怀孕期间会传播梅毒吗？
Sex Transm Dis. 2013 Apr;40(4):311-5. doi: 10.1097/OLQ.0b013e318285c5a7.
4
[Recent Advances in Laboratory Diagnosis of Syphilis].[梅毒实验室诊断的最新进展]
Mikrobiyol Bul. 2023 Jan;57(1):141-155. doi: 10.5578/mb.20239912.
5
VITREOUS TREPONEMAL ANTIBODY AS A SUPPLEMENTARY TEST TO SEROLOGY FOR THE CONFIRMATION OF SYPHILITIC CHORIORETINITIS.玻璃体苍白螺旋体抗体作为血清学检查的补充试验，用于确诊梅毒性脉络膜视网膜炎。
Retin Cases Brief Rep. 2020 Spring;14(2):166-169. doi: 10.1097/ICB.0000000000000676.
6
Limited efficacy of nontreponemal test combined with treponemal test in the initial syphilis screening algorithm.非梅毒螺旋体试验联合梅毒螺旋体试验在初始梅毒筛查算法中的效果有限。
J Med Microbiol. 2019 Feb;68(2):216-220. doi: 10.1099/jmm.0.000886. Epub 2018 Dec 20.
7
The tale of two serologic tests to screen for syphilis--treponemal and nontreponemal: does the order matter?梅毒血清学筛查试验——螺旋体和非螺旋体试验：检测顺序重要吗？
Sex Transm Dis. 2011 May;38(5):448-56. doi: 10.1097/OLQ.0b013e3182036a0f.
8
Syphilis testing algorithms using treponemal tests for initial screening--four laboratories, New York City, 2005-2006.2005 - 2006年纽约市四个实验室使用梅毒螺旋体检测进行初始筛查的梅毒检测算法
MMWR Morb Mortal Wkly Rep. 2008 Aug 15;57(32):872-5.
9
Usefulness in clinical practice of a point-of-care rapid test for simultaneous detection of nontreponemal and Treponema pallidum-specific antibodies in patients suffering from documented syphilis.即时检测快速试验在临床实践中对确诊梅毒患者同时检测非梅毒螺旋体和梅毒螺旋体特异性抗体的实用性。
Int J STD AIDS. 2013 Dec;24(12):944-50. doi: 10.1177/0956462413487328. Epub 2013 Sep 1.
10
Laboratory Evaluation of a Commercially Available Rapid Syphilis Test.商业用梅毒快速检测试剂的实验室评估
J Clin Microbiol. 2018 Sep 25;56(10). doi: 10.1128/JCM.00832-18. Print 2018 Oct.

引用本文的文献

1
Inflammatory Pseudotumor of the Anal Canal Mimicking Colorectal Cancer: Case Report and Hints to Improve a Patient's Fitness for Treatment and Prevention.肛管炎性假瘤酷似结直肠癌：病例报告及提高患者治疗适应性与预防的提示
Diagnostics (Basel). 2025 Apr 1;15(7):885. doi: 10.3390/diagnostics15070885.

本文引用的文献

1
An Uncommon Case of Syphilis With Simultaneous, Different Lesions: Moth-Eaten Alopecia, Syphilitic Keratoderma, and Psoriasiform Syphilis.一例罕见的梅毒病例：同时出现不同病变——虫蚀状脱发、梅毒性角化病和银屑病样梅毒。
Cureus. 2023 Nov 21;15(11):e49181. doi: 10.7759/cureus.49181. eCollection 2023 Nov.
2
Syphilis as Re-Emerging Disease, Antibiotic Resistance, and Vulnerable Population: Global Systematic Review and Meta-Analysis.梅毒作为复发性疾病、抗生素耐药性及脆弱人群：全球系统评价与荟萃分析
Pathogens. 2022 Dec 15;11(12):1546. doi: 10.3390/pathogens11121546.
3
Ofatumumab: A Review in Relapsing Forms of Multiple Sclerosis.
奥法妥木单抗：治疗多发性硬化症复发型的研究进展。
Drugs. 2022 Jan;82(1):55-62. doi: 10.1007/s40265-021-01650-7.
4
Cutaneous signs in infectious diseases.
Indian J Dermatol Venereol Leprol. 2022 May-Jun;88(4):569-575. doi: 10.25259/IJDVL_727_20.
5
Sexually Transmitted Infections Treatment Guidelines, 2021.《2021年性传播感染治疗指南》
MMWR Recomm Rep. 2021 Jul 23;70(4):1-187. doi: 10.15585/mmwr.rr7004a1.
6
Serological diagnosis of secondary syphilis in a Rituximab-treated patient: an emerging diagnostic challenge?利妥昔单抗治疗患者继发性梅毒的血清学诊断：一个新出现的诊断挑战？
J Eur Acad Dermatol Venereol. 2021 May;35(5):e350-e352. doi: 10.1111/jdv.17126. Epub 2021 Feb 5.
7
2020 European guideline on the management of syphilis.2020年欧洲梅毒管理指南。
J Eur Acad Dermatol Venereol. 2021 Mar;35(3):574-588. doi: 10.1111/jdv.16946. Epub 2020 Oct 22.
8
The Modern Epidemic of Syphilis.梅毒的现代流行情况
N Engl J Med. 2020 Feb 27;382(9):845-854. doi: 10.1056/NEJMra1901593.
9
Penicillin Allergy.青霉素过敏
N Engl J Med. 2019 Dec 12;381(24):2338-2351. doi: 10.1056/NEJMra1807761.
10
Syphilis and HIV: a dangerous combination.梅毒与艾滋病毒：危险的组合。
Lancet Infect Dis. 2004 Jul;4(7):456-66. doi: 10.1016/S1473-3099(04)01061-8.