Shan Guan-Yue, Wan Hui, Zhang Yu-Xin, Cheng Jun-Ya, Qiao Duan-Rui, Liu Yi-Ying, Shi Wen-Na, Li Hai-Jun
Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China.
Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130061, Jilin Province, China.
World J Hepatol. 2024 Oct 27;16(10):1142-1150. doi: 10.4254/wjh.v16.i10.1142.
In this editorial, we comment on the article by Mei . Nonalcoholic steatohepatitis (NASH) is a severe inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) with pathological features including steatosis, hepatocellular damage, and varying degrees of fibrosis. With the epidemic of metabolic diseases and obesity, the prevalence of NAFLD in China has increased, and it is now similar to that in developed countries; thus, NAFLD has become a major chronic liver disease in China. Human epidemiological data suggest that estrogen has a protective effect on NASH in premenopausal women and that sex hormones influence the development of liver disease. This review focuses on the pathogenesis, treatment, and relationship between NASH and other diseases as well as on the relationship between NASH and sex hormone metabolism, with the aim of providing new strategies for the treatment of NASH.
在这篇社论中，我们对梅的文章进行评论。非酒精性脂肪性肝炎（NASH）是非酒精性脂肪性肝病（NAFLD）的一种严重炎症亚型，其病理特征包括脂肪变性、肝细胞损伤和不同程度的纤维化。随着代谢性疾病和肥胖症的流行，NAFLD在中国的患病率有所上升，目前与发达国家相似；因此，NAFLD已成为中国主要的慢性肝病。人类流行病学数据表明，雌激素对绝经前女性的NASH具有保护作用，并且性激素会影响肝病的发展。本综述重点关注NASH的发病机制、治疗、与其他疾病的关系以及NASH与性激素代谢的关系，旨在为NASH的治疗提供新策略。
