逍遥散治疗非酒精性脂肪性肝病的生物活性成分及作用机制
Bioactive constituents and action mechanism of Xiaoyao San for treatment of non-alcoholic fatty liver disease.
作者信息
Qiu Xiao-Xia, Li Zheng
机构信息
Department of Research and Education, Shulan (Hangzhou) Hospital, Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310022, Zhejiang Province, China.
Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, College of Health Sciences, School of Life Sciences, Jiangsu Normal University, Xuzhou 221000, Jiangsu Province, China.
出版信息
World J Hepatol. 2024 Oct 27;16(10):1213-1215. doi: 10.4254/wjh.v16.i10.1213.
Abstract
Xiaoyao San (XYS) is a classic Chinese medicine prescription. It is traditionally used to relieve syndrome of "liver stagnation and spleen deficiency", a common syndrome type in traditional Chinese medicine, through soothing liver, tonifying spleen, and nourishing blood. Correspondingly, XYS has long application in the treatment of depression, dyspepsia and liver diseases. Given the rising of cutting-edge researches on XYS, there's a significant need to diligently uncover the bioactive constituents and action mechanisms of XYS for treating non-alcoholic fatty liver disease accordingly.
摘要
逍遥散（XYS）是一种经典的中药方剂。传统上，它通过疏肝、健脾、养血来缓解中医常见证型“肝郁脾虚”。相应地，逍遥散在抑郁症、消化不良和肝脏疾病的治疗中有着长期应用。鉴于对逍遥散前沿研究的不断增加，迫切需要相应地深入揭示逍遥散治疗非酒精性脂肪性肝病的生物活性成分及作用机制。
相似文献
1
Bioactive constituents and action mechanism of Xiaoyao San for treatment of non-alcoholic fatty liver disease.逍遥散治疗非酒精性脂肪性肝病的生物活性成分及作用机制
World J Hepatol. 2024 Oct 27;16(10):1213-1215. doi: 10.4254/wjh.v16.i10.1213.
2
Mechanism of Xiaoyao San in treating non-alcoholic fatty liver disease with liver depression and spleen deficiency: based on bioinformatics, metabolomics and experiments.逍遥散治疗肝郁脾虚型非酒精性脂肪性肝病的作用机制：基于生物信息学、代谢组学和实验研究。
J Biomol Struct Dyn. 2024 Jul;42(10):5128-5146. doi: 10.1080/07391102.2023.2231544. Epub 2023 Jul 13.
3
[Mechanism of Xiaoyao San in treatment of depression,breast hyperplasia,and functional dyspepsia based on network pharmacology].基于网络药理学探讨逍遥散治疗抑郁症、乳腺增生及功能性消化不良的作用机制
Zhongguo Zhong Yao Za Zhi. 2021 Aug;46(16):4230-4237. doi: 10.19540/j.cnki.cjcmm.20210520.702.
4
A unique insight for Xiaoyao San exerts antidepressant effects by modulating hippocampal glucose catabolism using stable isotope-resolved metabolomics.一项独特的见解表明，逍遥散通过使用稳定同位素分辨代谢组学调节海马体葡萄糖分解代谢来发挥抗抑郁作用。
J Ethnopharmacol. 2023 Jan 10;300:115702. doi: 10.1016/j.jep.2022.115702. Epub 2022 Sep 12.
5
Xiaoyao San attenuates hepatic steatosis through estrogen receptor α pathway in ovariectomized ApoE-/- mice.逍遥散通过雌激素受体 α 通路减轻去卵巢 ApoE-/- 小鼠的肝脂肪变性。
J Ethnopharmacol. 2022 Jan 10;282:114612. doi: 10.1016/j.jep.2021.114612. Epub 2021 Sep 5.
6
Studies on the potential link between antidepressant effect of Xiaoyao San and its pharmacological activity of hepatoprotection based on multi-platform metabolomics.基于多组学代谢组学探讨逍遥散抗抑郁作用与其保肝作用的潜在关联。
J Ethnopharmacol. 2020 Mar 1;249:112432. doi: 10.1016/j.jep.2019.112432. Epub 2019 Nov 29.
7
Mechanism Study of Xiaoyao San against Nonalcoholic Steatohepatitis-Related Liver Fibrosis Based on a Combined Strategy of Transcriptome Analysis and Network Pharmacology.基于转录组分析与网络药理学联合策略的逍遥散抗非酒精性脂肪性肝炎相关肝纤维化的机制研究
Pharmaceuticals (Basel). 2024 Aug 27;17(9):1128. doi: 10.3390/ph17091128.
8
Integrated Plasma Metabolomics and Gut Microbiota Analysis: The Intervention Effect of Jiawei Xiaoyao San on Liver Depression and Spleen Deficiency Liver Cancer Rats.整合血浆代谢组学与肠道微生物群分析：加味逍遥散对肝郁脾虚型肝癌大鼠的干预作用
Front Pharmacol. 2022 Jul 18;13:906256. doi: 10.3389/fphar.2022.906256. eCollection 2022.
9
Modified xiaoyao san combined with chemotherapy for breast cancer: A systematic review and meta-analysis of randomized controlled trials.加味逍遥散联合化疗治疗乳腺癌：一项随机对照试验的系统评价和Meta分析
Front Oncol. 2023 Mar 22;13:1050337. doi: 10.3389/fonc.2023.1050337. eCollection 2023.
10
Xiaoyao San, a Chinese herbal formula, ameliorates depression-like behavior in mice through the AdipoR1/AMPK/ACC pathway in hypothalamus.逍遥散通过下丘脑的 AdipoR1/AMPK/ACC 通路改善抑郁样行为的小鼠。
J Integr Med. 2022 Sep;20(5):442-452. doi: 10.1016/j.joim.2022.07.003. Epub 2022 Jul 25.
本文引用的文献
1
Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation regulating the sex hormones metabolism.逍遥散配方对肝脂肪变性和炎症的保肝作用及对性激素代谢的调节作用。
World J Hepatol. 2024 Jul 27;16(7):1051-1066. doi: 10.4254/wjh.v16.i7.1051.
2
Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model.逍遥散对大鼠抑郁模型运动能力和肝脏线粒体代谢组学的影响。
Chin Herb Med. 2023 Dec 1;16(1):132-142. doi: 10.1016/j.chmed.2023.09.004. eCollection 2024 Jan.
3
A multi-module structure labelled molecular network orients the chemical profiles of traditional Chinese medicine prescriptions: Xiaoyao San, as an example.多模块结构标记分子网络导向中药方剂的化学特征：以逍遥散为例。
J Chromatogr A. 2024 Jan 25;1715:464613. doi: 10.1016/j.chroma.2023.464613. Epub 2023 Dec 27.
4
Restraint stress promotes nonalcoholic steatohepatitis by regulating the farnesoid X receptor/NLRP3 signaling pathway.束缚应激通过调节法尼醇 X 受体/NLRP3 信号通路促进非酒精性脂肪性肝炎。
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 25;55(12):1961-1971. doi: 10.3724/abbs.2023240.
5
Dynamic network biomarker analysis and system pharmacology methods to explore the therapeutic effects and targets of Xiaoyaosan against liver cirrhosis.采用动态网络生物标志物分析和系统药理学方法探索逍遥散治疗肝硬化的疗效和作用靶点。
J Ethnopharmacol. 2022 Aug 10;294:115324. doi: 10.1016/j.jep.2022.115324. Epub 2022 Apr 27.
6
Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.基于网络药理学和转录组学分析开发具有木樨草素、甘草查尔酮 A、芦荟大黄素和芹菜素的新型抗肝纤维化配方。
Pharm Biol. 2021 Dec;59(1):1594-1606. doi: 10.1080/13880209.2021.1999275.
7
Xiaoyao San attenuates hepatic steatosis through estrogen receptor α pathway in ovariectomized ApoE-/- mice.逍遥散通过雌激素受体 α 通路减轻去卵巢 ApoE-/- 小鼠的肝脂肪变性。
J Ethnopharmacol. 2022 Jan 10;282:114612. doi: 10.1016/j.jep.2021.114612. Epub 2021 Sep 5.
8
Xiaoyaosan decoction alleviated rat liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways based on network pharmacology analysis.逍遥散通过网络药理学分析，经 TGFβ/Smad 和 Akt/FoxO3 信号通路缓解大鼠肝纤维化。
J Ethnopharmacol. 2021 Jan 10;264:113021. doi: 10.1016/j.jep.2020.113021. Epub 2020 May 30.
9
Simultaneous determination of multiple components in formula and preparations of Xiaoyaosan.消遥散配方及制剂中多组分的同时测定。
Nat Prod Res. 2021 Apr;35(7):1207-1211. doi: 10.1080/14786419.2019.1641808. Epub 2019 Jul 17.
10
Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model.使用Illumina测序技术对肝郁脾虚型功能性消化不良大鼠模型进行肠道微生物多样性分析及逍遥散的干预作用
World J Gastroenterol. 2017 Feb 7;23(5):810-816. doi: 10.3748/wjg.v23.i5.810.
Zotero 插件