Department of Nutrition and Food Hygiene, School of Public Health Institute of Nutrition, Zhongshan Hospital, Fudan University Shanghai China.
Department of Cardiology Kailuan General Hospital Tangshan China.
J Am Heart Assoc. 2024 Nov 5;13(21):e035813. doi: 10.1161/JAHA.124.035813. Epub 2024 Oct 30.
The potential clinical implication of sleep talking in relation to stroke has not been explored to date. This study aimed to prospectively examine the association between sleep talking and the risk of developing stroke in a community-based cohort.
Included were 8001 participants (mean age, 54 years) of the Kailuan Study, China. Sleep talking was measured by a questionnaire in 2012. Cases of incident stroke were confirmed by review of medical records. Cox proportional hazards models were used to explore the association between sleep talking and stroke, adjusting for several sleep parameters (ie, insomnia, daytime sleepiness, sleep duration, snoring, and use of hypnotics) and other potential confounders. During 8 years of follow-up, 333 incident stroke cases were identified. Relative to participants without sleep talking at baseline, those with sleep talking had a higher risk of developing stroke (hazard ratio [HR], 1.30 [95% CI, 1.03-1.65]), adjusting for potential confounders. Compared with participants without probable rapid eye movement sleep behavior disorder and sleep talking, those with sleep talking and probable rapid eye movement sleep behavior disorder had a higher risk of stroke (adjusted HR, 1.93 [95% CI, 1.40-2.66]).
The presence of sleep talking was associated with a higher risk of developing stroke. Future studies with cases of clinically confirmed sleep talking and a longer follow-up would be appropriate to further investigate this association.
目前尚未探讨与中风相关的梦呓的潜在临床意义。本研究旨在前瞻性地研究在基于社区的队列中，梦呓与中风风险之间的关系。
该研究纳入了中国开滦研究中的 8001 名参与者（平均年龄为 54 岁）。在 2012 年通过问卷来测量梦呓。通过审查病历来确认新发中风病例。使用 Cox 比例风险模型来探索梦呓与中风之间的关联，调整了几个睡眠参数（即失眠、日间嗜睡、睡眠时间、打鼾和使用催眠药）和其他潜在混杂因素。在 8 年的随访期间，共发现 333 例中风事件。与基线时没有梦呓的参与者相比，有梦呓的参与者发生中风的风险更高（风险比 [HR]，1.30 [95%CI，1.03-1.65]），调整了潜在混杂因素。与没有可能的快速眼动睡眠行为障碍和梦呓的参与者相比，有梦呓和可能的快速眼动睡眠行为障碍的参与者发生中风的风险更高（调整后的 HR，1.93 [95%CI，1.40-2.66]）。
存在梦呓与发生中风的风险增加有关。未来的研究应该包括有临床确诊的梦呓和更长的随访时间，以进一步研究这种关联。
