短暂性全面性遗忘症（TGA）与维生素B12饮食摄入量的关联

Association of Transient Global Amnesia (TGA) With Dietary Intake of Vitamin B12.

作者信息

Mousavi Shalmani Seyedeh Hayedeh, Mahamoudi Zahra, Nooriani Narjes, Saeedirad Zahra, Hassanpour Ardekanizadeh Naeemeh, Tavakoli Aryan, Shekari Soheila, Mirshafaei Masoomeh Alsadat, Mousavi Mele Mahdi, Mirzaee Pouya, Gholamalizadeh Maryam, Bahmani Parsa, Khoshdooz Sara, Doaei Saeid

机构信息

Guilan University of Medical Sciences, Rasht, Iran.

Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.

出版信息

Arch Clin Neuropsychol. 2025 Apr 27;40(3):375-381. doi: 10.1093/arclin/acae091.

DOI:10.1093/arclin/acae091

PMID:39474898

Abstract

BACKGROUND

Transient global amnesia (TGA), which is described as short-term amnesia, may be influenced by some dietary components involved in brain function. The aim of the present study was to assess the connection between TGA and dietary intake of vitamin B12.

METHODS

This cross-sectional study was conducted on 258 people with TGA and 520 people without TGA in Sabzevar, Iran. All participants were screened for TGA (ICD-10 code: G45.4). A validated Food Frequency Questionnaire (FFQ) was utilized to estimate the dietary intake of vitamin B12. Different models of logistic regression were used to determine the association between TGA and dietary intake of vitamin B12 after adjusting the confounders.

RESULTS

There was an inverse association between the risk of TGA and the intake of vitamin B12 (OR = 0.94, CI 95%: 0.89-0.99, p = .02, effect size: -0.04). The result did not change after adjustment for age, gender, education, job, and marital status (OR = 0.93, CI 95%: 0.88-0.98, p = .01, effect size: -0.03). The result remained significant after additional adjustments for body mass index (BMI) and physical activity (OR = 0.94, CI 95%: 0.89-0.99, p = .03, effect size: -0.04), and after further adjustments for the underlying diseases, including diabetes, hypertension, and stroke (OR = 0.86, CI 95%: 0.81-0.92, p < .01, effect size: -0.10).

CONCLUSION

Vitamin B12 deficiency may increase the risk of TGA and should be considered as a potential concern for people at risk for TGA. Further studies are needed to validate these findings and to discover the underlying mechanisms of the effects of vitamin B12 on TGA.

摘要

背景

短暂性全面性遗忘症（TGA）被描述为短期失忆，可能受到一些与脑功能相关的饮食成分的影响。本研究的目的是评估TGA与维生素B12饮食摄入量之间的联系。

方法

这项横断面研究在伊朗萨卜泽瓦尔的258名TGA患者和520名非TGA患者中进行。所有参与者均接受TGA筛查（国际疾病分类第十版代码：G45.4）。使用经过验证的食物频率问卷（FFQ）来估计维生素B12的饮食摄入量。在调整混杂因素后，使用不同的逻辑回归模型来确定TGA与维生素B12饮食摄入量之间的关联。

结果

TGA风险与维生素B12摄入量之间存在负相关（比值比=0.94，95%置信区间：0.89-0.99，p=0.02，效应大小：-0.04）。在调整年龄、性别、教育程度、工作和婚姻状况后，结果没有改变（比值比=0.93，95%置信区间：0.88-0.98，p=0.01，效应大小：-0.03）。在进一步调整体重指数（BMI）和身体活动后，结果仍然显著（比值比=0.94，95%置信区间：0.89-0.99，p=0.03，效应大小：-0.04），在进一步调整包括糖尿病、高血压和中风在内的基础疾病后，结果仍然显著（比值比=0.86，95%置信区间：0.81-0.92，p<0.01，效应大小：-0.10）。