饮食中脂肪摄入量与短暂性全面性遗忘症（TGA）之间的关联。

The association between dietary intake of fats and transient global amnesia (TGA).

作者信息

Mahmoudi Zahra, Tajik Ali, Vahdat Mahsa, Mobarakeh Khadijeh Abbasi, Saeedirad Zahra, Azaryan Fatemeh, Amjadi Arezoo, Alami Farkhondeh, Valisoltani Neda, Mirshafaei Masoomeh Alsadat, Khoshdooz Sara, Gholamalizadeh Maryam, Doaei Saeid, Kooshki Akram

机构信息

Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.

University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

出版信息

Nutr Neurosci. 2025 Feb;28(2):149-155. doi: 10.1080/1028415X.2024.2359866. Epub 2024 Jul 16.

DOI:10.1080/1028415X.2024.2359866

PMID:39012761

Abstract

BACKGROUND

Different types of dietary fat may influence memory and cognitive functions. This study aimed to investigate the association between dietary fat intake and transient global amnesia (TGA).

METHODS

This case-control study was conducted using Persian Sabzevar cohort data on 258 individuals with TGA and 520 individuals without amnesia in Sabzevar Iran. The food frequency questionnaire (FFQ) was used to assess the intake of dietary fats of the participants. All study participants were screened for TGA by a neurologist and their status was determined based on the diagnostic symptoms defined by the Kaplan and Hodges criteria.

RESULTS

There was an inverse association between the risk of TGA and dietary intake of alpha-linolenic acid (ALA) (OR = 0.94, CI95%:0.88-0.99, = 0.01). Also, a positive association was observed between TGA and dietary intake of n-6 fatty acids (OR = 1.18, CI 95%: 1.04-1.33, = 0.01). The results remained significant after adjustment for age, sex, education, job, marital status, physical activity, BMI, and calorie intake.

CONCLUSION

Omega-3 fatty acids may have beneficial effects; however, omega-6 fatty acids may have adverse effects on the risk of amnesia. Further longitudinal studies are warranted.

摘要

背景

不同类型的膳食脂肪可能会影响记忆和认知功能。本研究旨在调查膳食脂肪摄入量与短暂性全面性遗忘症（TGA）之间的关联。

方法

本病例对照研究使用了伊朗萨卜泽瓦尔的波斯萨卜泽瓦尔队列数据，该队列中有258例TGA患者和520例无遗忘症的个体。采用食物频率问卷（FFQ）评估参与者的膳食脂肪摄入量。所有研究参与者均由神经科医生进行TGA筛查，并根据卡普兰和霍奇斯标准定义的诊断症状确定其状态。

结果

TGA风险与α-亚麻酸（ALA）的膳食摄入量之间存在负相关（OR = 0.94，95%CI：0.88 - 0.99，P = 0.01）。此外，观察到TGA与n-6脂肪酸的膳食摄入量之间存在正相关（OR = 1.18，95%CI：1.04 - 1.33，P = 0.01）。在对年龄、性别、教育程度、工作、婚姻状况、身体活动、BMI和卡路里摄入量进行调整后，结果仍然显著。