Clementel Damiano, Arrías Paula Nazarena, Mozaffari Soroush, Osmanli Zarifa, Castro Ximena Aixa, Ferrari Carlo, Kajava Andrey V, Tosatto Silvio C E, Monzon Alexander Miguel
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Nucleic Acids Res. 2025 Jan 6;53(D1):D575-D581. doi: 10.1093/nar/gkae965.
RepeatsDB (URL: https://repeatsdb.org) stands as a key resource for the classification and annotation of Structured Tandem Repeat Proteins (STRPs), incorporating data from both the Protein Data Bank (PDB) and AlphaFoldDB. This latest release features substantial advancements, including annotations for over 34 000 unique protein sequences from >2000 organisms, representing a fifteenfold increase in coverage. Leveraging state-of-the-art structural alignment tools, RepeatsDB now offers faster and more precise detection of STRPs across both experimental and predicted structures. Key improvements also include a redesigned user interface and enhanced web server, providing an intuitive browsing experience with improved data searchability and accessibility. A new statistics page allows users to explore database metrics based on repeat classifications, while API enhancements support scalability to manage the growing volume of data. These advancements not only refine the understanding of STRPs but also streamline annotation processes, further strengthening RepeatsDB's role in advancing our understanding of STRP functions.
