Kemmler Emanuel, Lemfack Marie Chantal, Goede Andrean, Gallo Kathleen, Toguem Serge M T, Ahmed Waqar, Millberg Iris, Preissner Saskia, Piechulla Birgit, Preissner Robert
Institute for Physiology & Science-IT, Charité - University Medicine Berlin, 10115 Berlin, Germany.
Institute of Biological Sciences, University of Rostock, Albert-Einstein-Straße 3, 18059 Rostock, Germany.
Nucleic Acids Res. 2025 Jan 6;53(D1):D1692-D1696. doi: 10.1093/nar/gkae961.
Metabolomic microbiome research has become an important topic for understanding agricultural, ecological as well as health correlations. Only the determination of both the non-volatile and the volatile organic compound (mVOC) production by microorganisms allows a holistic view for understanding the complete potential of metabolomes and metabolic capabilities of bacteria. In the recent past, more and more bacterial headspaces and culture media were analyzed, leading to an accumulation of about 3500 mVOCs in the updated mVOC 4.0 database, including compounds synthesized by the newly discovered non-canonical terpene pathway. Approximately 10% of all mVOCs can be assigned with a biological function, some mVOCs have the potential to impact agriculture in the future (e.g. eco-friendly pesticides) or animal and human health care. mVOC 4.0 offers various options for exploring extensively annotated mVOC data from different perspectives, including improved mass spectrometry matching. The mVOC 4.0 database includes literature searches with additional relevant keywords, making it the most up-to-date and comprehensive publicly available mVOC platform at: http://bioinformatics.charite.de/mvoc.
代谢组学微生物组研究已成为理解农业、生态以及健康关联的重要课题。只有确定微生物产生的非挥发性和挥发性有机化合物（mVOC），才能全面了解代谢组的全部潜力和细菌的代谢能力。最近，越来越多的细菌顶空和培养基得到分析，在更新的mVOC 4.0数据库中积累了约3500种mVOC，包括通过新发现的非经典萜烯途径合成的化合物。所有mVOC中约10%可被赋予生物学功能，一些mVOC未来有可能影响农业（如环保型农药）或动物及人类医疗保健。mVOC 4.0提供了多种从不同角度广泛探索注释过的mVOC数据的选项，包括改进的质谱匹配。mVOC 4.0数据库包括使用其他相关关键词的文献检索，使其成为最及时、最全面的公开可用mVOC平台，网址为：http://bioinformatics.charite.de/mvoc 。
