University of Rostock, Institute of Biological Sciences, Rostock 18059, Germany, Charité-University Medicine Berlin, Structural Bioinformatics Group, Institute of Physiology & Experimental Clinical Research Center, Berlin 13125, Germany and Charité-University Medicine Berlin, Division of General Pediatrics, Department of Pediatric Oncology and Hematology, Berlin 13353, Germany.
Nucleic Acids Res. 2014 Jan;42(Database issue):D744-8. doi: 10.1093/nar/gkt1250. Epub 2013 Dec 5.
Scents are well known to be emitted from flowers and animals. In nature, these volatiles are responsible for inter- and intra-organismic communication, e.g. attraction and defence. Consequently, they influence and improve the establishment of organisms and populations in ecological niches by acting as single compounds or in mixtures. Despite the known wealth of volatile organic compounds (VOCs) from species of the plant and animal kingdom, in the past, less attention has been focused on volatiles of microorganisms. Although fast and affordable sequencing methods facilitate the detection of microbial diseases, however, the analysis of signature or fingerprint volatiles will be faster and easier. Microbial VOCs (mVOCs) are presently used as marker to detect human diseases, food spoilage or moulds in houses. Furthermore, mVOCs exhibited antagonistic potential against pathogens in vitro, but their biological roles in the ecosystems remain to be investigated. Information on volatile emission from bacteria and fungi is presently scattered in the literature, and no public and up-to-date collection on mVOCs is available. To address this need, we have developed mVOC, a database available online at http://bioinformatics.charite.de/mvoc.
气味众所周知是由花朵和动物散发出来的。在自然界中，这些挥发性物质负责生物体内和生物之间的通讯，例如吸引和防御。因此，它们通过单一化合物或混合物的形式影响和改善生态位中生物和种群的建立。尽管已知植物和动物王国的物种中含有丰富的挥发性有机化合物 (VOCs)，但过去对微生物挥发性物质的关注较少。尽管快速且经济实惠的测序方法有助于检测微生物疾病，但分析特征或指纹挥发性物质将更快且更容易。微生物 VOCs (mVOCs) 目前被用作标记物来检测人体疾病、食物变质或房屋内的霉菌。此外，mVOCs 在体外表现出对病原体的拮抗潜力，但它们在生态系统中的生物学作用仍有待研究。目前有关细菌和真菌挥发性排放的信息在文献中分散，并且没有关于 mVOCs 的公共和最新集合。为了满足这一需求，我们开发了 mVOC，一个可在线访问的数据库，网址为 http://bioinformatics.charite.de/mvoc。
