多糖果聚糖对Lewis肺癌两种变体细胞致癌性的不同影响。
Different effects of the polysaccharide levan on the oncogenicity of cells of two variants of Lewis lung carcinoma.
作者信息
Stark Y, Leibovici J
出版信息
Br J Exp Pathol. 1986 Feb;67(1):141-7.
Abstract
A marked difference in sensitivity to the direct effect of the polysaccharide levan on tumour cells was observed between two variants of malignancy of Lewis lung carcinoma: cells of the more malignant variant (3LL-M) were much more sensitive to the drug than those of the less malignant tumour (3LL). A gradual decrease in tumorigenicity following preincubation with increasing levan concentrations was observed with both variants, but statistically significant inhibition was observed at lower levan concentrations with 3LL-M than with 3LL.
摘要
在Lewis肺癌的两种恶性变体之间观察到对多糖果聚糖对肿瘤细胞直接作用的敏感性存在显著差异：恶性程度较高的变体（3LL-M）的细胞对该药物的敏感性远高于恶性程度较低的肿瘤（3LL）的细胞。两种变体在与浓度不断增加的果聚糖预孵育后致瘤性均逐渐降低，但与3LL相比，3LL-M在较低果聚糖浓度下观察到具有统计学意义的抑制作用。
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本文引用的文献
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Infection-promoting activity of levan and dextran as a function of degree of polymerization.作为聚合度函数的果聚糖和葡聚糖的促感染活性。
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Spontaneous AKR lymphomas differ in their degree of malignancy and sensitivity to the polysaccharide levan.自发性AKR淋巴瘤在恶性程度和对多糖果聚糖的敏感性方面存在差异。
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Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential.具有高转移潜能的小鼠乳腺癌细胞变体中透明质酸合成增加。
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Direct antitumor effect of the polysaccharide levan in mice: effects of drug concentration and time and temperature of incubation.多糖左聚糖对小鼠的直接抗肿瘤作用：药物浓度、孵育时间和温度的影响
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Animal models for tumor progression (short review).肿瘤进展的动物模型（简短综述）。
Anticancer Res. 1984 May-Jun;4(3):165-8.
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