Leibovici J, Michowitz M, Shezen E, Wolman M, Sandbank U
Oncology. 1981;38(1):31-4. doi: 10.1159/000225517.
A combined treatment modality including surgical excision and daily injections of high molecular levan seemed to be effective against Lewis lung carcinoma in C57BL mice. The inhibitory effect of levan on tumor growth in mice treated by resection of the primary tumor was demonstrated as follows: (1) recurrence of primary tumors was less in levan-treated mice compared to untreated animals; (2) metastases were less numerous in the levan-treated animals; (3) levan treatment partly prevented loss in body weight, and (4) it increased the survival rate. Recurrence of primary tumors appeared to be more efficiently inhibited by local levan treatment, while systemic (i.p.) administration was more effective than local treatment in preventing metastases. The mechanism of inhibition of tumor growth was related to accumulation of macrophages around the metastases.
一种联合治疗方式，包括手术切除和每日注射高分子量左聚糖，似乎对C57BL小鼠的Lewis肺癌有效。左聚糖对经原发性肿瘤切除治疗的小鼠肿瘤生长的抑制作用如下所示：（1）与未治疗的动物相比，左聚糖治疗的小鼠原发性肿瘤复发较少；（2）左聚糖治疗的动物转移灶较少；（3）左聚糖治疗部分防止了体重减轻，并且（4）提高了存活率。局部左聚糖治疗似乎能更有效地抑制原发性肿瘤的复发，而全身（腹腔内）给药在预防转移方面比局部治疗更有效。肿瘤生长抑制机制与转移灶周围巨噬细胞的聚集有关。
