脾切除术对一种免疫调节多糖和一种细胞毒性药物治疗Lewis肺癌的影响。
Effect of splenectomy on treatment of Lewis lung carcinoma by an immunomodulatory polysaccharide and a cytotoxic agent.
作者信息
Michowitz M, Kopel S, Hoenig S, Leibovici J
出版信息
J Surg Oncol. 1987 Apr;34(4):268-71. doi: 10.1002/jso.2930340412.
The effect of the spleen on the efficiency of chemotherapy (cyclophosphamide) and immunotherapy (the polysaccharide levan) of C57BL mice bearing the Lewis lung carcinoma was studied. The development of Lewis lung carcinoma caused a gradual splenomegaly in the C57BL mice. Splenectomy did not, however, affect tumor growth in the nontreated host. Levan induced a pronounced splenomegaly. Splenectomy reduced markedly the antitumoral effect of the polysaccharide. These results indicate that spleen elements participate in the inhibitory activity of levan. By contrast, splenectomy had no effect on the efficiency of treatment of cyclophosphamide.
研究了脾脏对携带Lewis肺癌的C57BL小鼠化疗（环磷酰胺）和免疫治疗（多糖左聚糖）效果的影响。Lewis肺癌的发展导致C57BL小鼠脾脏逐渐肿大。然而，脾切除术对未经治疗的宿主的肿瘤生长没有影响。左聚糖可诱导明显的脾肿大。脾切除术显著降低了多糖的抗肿瘤作用。这些结果表明脾脏成分参与了左聚糖的抑制活性。相比之下，脾切除术对环磷酰胺的治疗效果没有影响。
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