Hodgson J T, Jones R D
Br J Ind Med. 1986 Mar;43(3):158-64. doi: 10.1136/oem.43.3.158.
A national study of British asbestos workers is briefly described and the mortality experience of 31 150 male asbestos workers in England and Wales who had been medically examined at least once as part of that survey is presented. The survey population is divided into workers with occupational exposure to asbestos before the inception of the 1969 Asbestos Regulations and those who worked with asbestos only after 1969. Of the 1128 who had died, 897 had worked before 1969; 34 of the death certificates received for these men mentioned mesothelioma and for another nine asbestosis was reported in the absence of mesothelioma or lung cancer. A statistically significant excess of lung cancer (SMR 136) was found. For the post-1969 workers, one case of asbestosis and one case of mesothelioma were reported, but further investigation of these cases showed probable occupational exposure to asbestos many years before 1969. The time from first exposure for this section of the population is too short to exclude an excess of asbestos related disease. The most noticeable excess of asbestos related disease was seen among the insulation workers who had more than twice (SMR 256) the expected number of deaths from lung cancer, and for whom almost 10% of all death certificates mentioned mesothelioma. No excess of any alimentary tract cancer was found and the population showed a significant deficit of large bowel cancer mortality (SMR 54).
简要介绍了一项针对英国石棉工人的全国性研究,并呈现了在该调查中至少接受过一次医学检查的31150名英格兰和威尔士男性石棉工人的死亡情况。调查人群分为在1969年《石棉条例》颁布之前有职业性石棉接触史的工人以及仅在1969年之后从事石棉工作的工人。在已死亡的1128人中,897人在1969年之前工作;这些人收到的死亡证明中有34份提到了间皮瘤,另有9份报告了在没有间皮瘤或肺癌的情况下患有石棉肺。发现肺癌存在统计学上的显著超额(标准化死亡比为136)。对于1969年之后的工人,报告了1例石棉肺和1例间皮瘤,但对这些病例的进一步调查显示,他们在1969年之前很多年可能就有职业性石棉接触史。这部分人群从首次接触到现在的时间太短,无法排除石棉相关疾病超额的可能性。在绝缘工人中,石棉相关疾病的超额最为明显,他们的肺癌死亡人数超过预期两倍多(标准化死亡比为256),所有死亡证明中近10%提到了间皮瘤。未发现任何消化道癌症超额,且该人群的大肠癌死亡率显著低于预期(标准化死亡比为54)。