Faculty of Nutrition, Federal University of Goias, Setor Leste Universitário, Rua 227, Quadra 68 S/N°, Goiânia, GO, CEP 74605080, Brazil.
Support Care Cancer. 2024 Oct 30;32(11):757. doi: 10.1007/s00520-024-08954-w.
The aim of this study is to verify the correlation between hemoglobin (Hb) and hematocrit (Ht) levels with phase angle (PhA) values in patients with cancer of the gastrointestinal tract and accessory digestive organs. A cross-sectional study was conducted with 82 patients (38 females/44 males) diagnosed with cancer of gastrointestinal tract and accessory organs of digestion. Hb (g/dL) and Ht (%) levels were assessed by the cyanomethemoglobin and microhematocrit methods, respectively. Body composition and PhA were evaluated by the bioelectrical impedance analysis (BIA). The cut-off point used to classify patients with low PhA was set < 4°. Fifty-five (67%) of patients had PhA ≥ 4° values. We observed that body weight, BMI, fat mass, % weight loss, Ht, and Hb were higher in the PhA ≥ 4° group than in the PhA < 4° group. In the regression analysis, we found a positive association between PhA, Ht, and Hb without and after adjustment for sex, age, BMI, and type of treatment. In mixed cancer patients, there was a positive correlation between blood-red cell markers and PhA. This may be evidence that we can use of hematological parameters to suggest changes in PhA values during oncological treatment.
本研究旨在验证血红蛋白（Hb）和血细胞比容（Ht）水平与胃肠道和附属消化器官癌症患者的相位角（PhA）值之间的相关性。对 82 名（38 名女性/44 名男性）被诊断患有胃肠道和附属消化器官癌症的患者进行了横断面研究。通过氰化高铁血红蛋白法和微量血细胞比容法分别评估 Hb（g/dL）和 Ht（%）水平。通过生物电阻抗分析（BIA）评估身体成分和 PhA。将 PhA < 4°作为分类低值 PhA 患者的截断点。55（67%）名患者的 PhA 值≥4°。我们观察到 PhA≥4°组的体重、BMI、体脂肪量、体重减轻百分比、Ht 和 Hb 均高于 PhA < 4°组。在回归分析中，我们发现 PhA、Ht 和 Hb 与性别、年龄、BMI 和治疗类型无关和调整后均呈正相关。在混合癌症患者中，血液红细胞标志物与 PhA 之间存在正相关。这可能表明我们可以使用血液学参数来提示癌症治疗过程中 PhA 值的变化。
