Barrea Luigi, Muscogiuri Giovanna, Macchia Paolo Emidio, Di Somma Carolina, Falco Andrea, Savanelli Maria Cristina, Colao Annamaria, Savastano Silvia
I.O.S. COLEMAN Srl, Acerra, 80011 Naples, Italy.
Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
Nutrients. 2017 Feb 17;9(2):151. doi: 10.3390/nu9020151.
The Mediterranean diet is a healthy dietary pattern known to actively modulate the cell membrane properties. Phase angle (PhA) is a direct measure by Bioelectrical Impedance Analysis (BIA) used as marker of cell membrane integrity. Both food behaviour and PhA are influenced by age, sex and body weight. The aim of this study was to cross-sectionally evaluate the association between the adherence to Mediterranean diet and PhA in 1013 healthy adult patients stratified according to sex, age, and body mass index (BMI). The adherence to the Mediterranean diet was evaluated using the PREvención con DIeta MEDiterránea (PREDIMED) questionnaire. PhA was calculated by BIA phase-sensitive system (50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy Akern). In both sexes, at ROC analysis a PREDIMED score ≥ 6 predicted a PhA beyond the median value. At the multivariate analysis, among PREDIMED score, age, and BMI, the PREDIMED score was the major determinant of PhA, explaining 44.5% and 47.3% of PhA variability, in males and females respectively ( < 0.001). A novel association was reported between the adherence to the Mediterranean diet and PhA, independently of sex, age, and body weight. This association uncovered a new potential benefit of the Mediterranean diet on health outcomes, as in both sexes higher adherence to the Mediterranean diet was associated to larger PhAs, as expression of cell membrane integrity.
地中海饮食是一种已知能积极调节细胞膜特性的健康饮食模式。相角（PhA）是通过生物电阻抗分析（BIA）进行的直接测量，用作细胞膜完整性的标志物。饮食行为和相角均受年龄、性别和体重的影响。本研究的目的是对1013名根据性别、年龄和体重指数（BMI）分层的健康成年患者进行横断面评估，以探讨遵循地中海饮食与相角之间的关联。采用地中海饮食预防（PREDIMED）问卷评估对地中海饮食的遵循情况。相角由BIA相敏系统（50 kHz BIA 101 RJL，意大利佛罗伦萨的阿克恩生物研究公司）计算得出。在两性中，经ROC分析，PREDIMED评分≥6预测相角超过中位数。在多变量分析中，在PREDIMED评分、年龄和BMI中，PREDIMED评分是相角的主要决定因素，分别解释了男性和女性相角变异性的44.5%和47.3%（<0.001）。报告了遵循地中海饮食与相角之间的一种新关联，该关联独立于性别、年龄和体重。这种关联揭示了地中海饮食对健康结果的一种新的潜在益处，因为在两性中，更高程度地遵循地中海饮食与更大的相角相关，这是细胞膜完整性的一种表现。
