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翻译：翻译后，我们会给你一个简洁明了的中文译文，让你快速了解文本的主要内容。

The regulation of pyroptosis by post-translational modifications: molecular mechanisms and therapeutic targets.

机构信息

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Centre for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Centre for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.

出版信息

EBioMedicine. 2024 Nov;109:105420. doi: 10.1016/j.ebiom.2024.105420. Epub 2024 Oct 30.

DOI:10.1016/j.ebiom.2024.105420
PMID:39476537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11564932/
Abstract

Pyroptosis, a type of programmed cell death mediated by gasdermin family proteins, releases a large amount of immune stimulatory substances, which further contribute to inflammation and elicit an adaptive immune response against tumours and pathogens. And it occurs through multiple pathways that involve the activation of specific caspases and the cleavage of gasdermins. Post-translational modifications (PTMs) could influence the chemical properties of the modified residues and neighbouring regions, ultimately affecting the activity, stability, and functions of proteins to regulate pyroptosis. Many studies have been conducted to explore the influence of PTMs on the regulation of pyroptosis. In this review, we provide a comprehensive summary of different types of PTMs that influence pyroptosis, along with their corresponding modifying enzymes. Moreover, it elaborates on the specific contributions of different PTMs to pyroptosis and delves into how the regulation of these modifications can be leveraged for therapeutic interventions in cancer and inflammatory diseases.

摘要

细胞焦亡是一种由gasdermin 家族蛋白介导的程序性细胞死亡方式，其会释放大量的免疫刺激物质，从而进一步促进炎症反应，并引发针对肿瘤和病原体的适应性免疫反应。它通过多种途径发生，涉及特定半胱天冬酶的激活和 gasdermins 的切割。翻译后修饰（PTMs）可以影响修饰残基和邻近区域的化学性质，最终影响蛋白质的活性、稳定性和功能，从而调节细胞焦亡。许多研究已经探讨了 PTMs 对细胞焦亡调节的影响。在这篇综述中，我们全面总结了影响细胞焦亡的不同类型的 PTMs 及其相应的修饰酶，并详细阐述了不同 PTMs 对细胞焦亡的具体贡献，以及如何利用这些修饰的调节来进行癌症和炎症性疾病的治疗干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/f23b91f74a24/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/72284d24c02d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/39623a83c460/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/f23b91f74a24/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/72284d24c02d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/39623a83c460/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ad/11564932/f23b91f74a24/gr3.jpg

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本文引用的文献

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2
Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms.无分裂依赖性的古真核 GASDermins 激活及其结构机制。
Science. 2024 May 17;384(6697):adm9190. doi: 10.1126/science.adm9190.
3
Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases.
半胱天冬酶作为程序性细胞死亡的主要调节因子：细胞凋亡、细胞焦亡及其他。
Exp Mol Med. 2025 Jun 24. doi: 10.1038/s12276-025-01470-9.
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Effect of the modified Atkins diet on NLRP3, caspase-1, IL-ιβ, and IL-10 in patients with tetralogy of Fallot undergoing open-heart surgery: A randomized controlled trial.改良阿特金斯饮食对法洛四联症患者心脏直视手术中NLRP3、半胱天冬酶-1、白细胞介素-1β和白细胞介素-10的影响：一项随机对照试验。
Narra J. 2025 Apr;5(1):e2138. doi: 10.52225/narra.v5i1.2138. Epub 2025 Mar 24.
5
Macrophage pyroptosis and its crucial role in ALI/ARDS.巨噬细胞焦亡及其在急性肺损伤/急性呼吸窘迫综合征中的关键作用。
Front Immunol. 2025 Feb 14;16:1530849. doi: 10.3389/fimmu.2025.1530849. eCollection 2025.
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