Levin A M, Vnukov V V
Nauchnye Doki Vyss Shkoly Biol Nauki. 1986(1):57-60.
Dynamics of hemoglobin, ceruloplasmin concentration, the changes of chemiluminescence in blood plasma and kinetics of rat erythrocyte heat denaturation during consequent exposition of high altitude hypoxia and hyperbaric oxygenation have been studied. Severe hypoxia causes the decrease of extraerythrocyte hemoglobin and oxidase activity of ceruloplasmin. Reoxygenation results in significant increase of blood plasma chemiluminescence with simultaneous increase of extraerythrocyte hemoglobin level and with modification of surface structure of the erythrocyte membranes. Possible pathways of activation of oxygen-dependent of free-radical processes during reoxygenation are discussed.
研究了大鼠在持续暴露于高原低氧和高压氧合过程中血红蛋白、铜蓝蛋白浓度的动态变化、血浆化学发光的变化以及红细胞热变性动力学。严重低氧导致红细胞外血红蛋白和铜蓝蛋白氧化酶活性降低。再给氧导致血浆化学发光显著增加，同时红细胞外血红蛋白水平升高，红细胞膜表面结构改变。讨论了再给氧过程中氧依赖性自由基过程激活的可能途径。
