Mogil'nitskaia L V, Prokof'ev V N, Morgulis G L
Ukr Biokhim Zh (1978). 1996 Jan-Feb;68(1):96-100.
Effects of prolonged action of low-pressure oxygen (0.3 MPa, 5h) on the free-radical oxidation (FRO) intensity were investigated just after oxygen exposure and 1, 3, 7, days after that. The FRO increase against the background of the anti-radical systems depression was shown by means of blood plasma chemiluminescent analysis. Under these conditions SOD activity and the content of diene conjugates and Schiff's bases increase in erythrocyte membranes. The displacement of equilibrium between pro- and antioxidants and antioxidants contents towards the latter took place in blood plasma on the 1st day after oxygen exposure. The erythrocyte SOD activity was raised while catalase activity was diminished. The last one was accompanied with the decrease in erythrocyte membrane diene conjugates amount. The secondary blood plasma and erythrocyte membrane FRO elevation was observed on the 3rd day after the exposure and, it was held on the 7th day after hyperoxia. The FRO increase in post-hyperoxia period was established.
研究了低压氧（0.3MPa，5小时）长时间作用后即刻以及之后1天、3天、7天对自由基氧化（FRO）强度的影响。通过血浆化学发光分析表明，在抗自由基系统抑制的背景下FRO增加。在这些条件下，红细胞膜中的超氧化物歧化酶（SOD）活性、二烯共轭物和席夫碱的含量增加。氧暴露后第1天，血浆中促氧化剂和抗氧化剂之间的平衡以及抗氧化剂含量向后者发生了位移。红细胞SOD活性升高，而过氧化氢酶活性降低。后者伴随着红细胞膜中二烯共轭物数量的减少。暴露后第3天观察到血浆和红细胞膜的继发性FRO升高，并在高氧后第7天持续存在。确定了高氧后时期FRO增加。
