Program in Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Center for Global Non-Communicable Diseases Research and Training, Johns Hopkins University, Baltimore, Maryland, USA.
BMJ Open. 2024 Oct 29;14(10):e088235. doi: 10.1136/bmjopen-2024-088235.
Hypertension and type 2 diabetes mellitus (T2DM) are two highly prevalent non-communicable diseases worldwide, both leading to disability and premature mortality in low-and-middle-income countries (LMICs). Nutritional interventions towards a healthier dietary pattern or food and nutrients intake have an important role on the management of this disease. This systematic review aims to evaluate the effect of nutritional interventions on the management of blood pressure and glycaemia in adults with hypertension and T2DM from LMICs.
We will conduct a systematic review of randomised controlled trials (RCTs) on the effect of nutritional interventions on blood pressure and glycaemia in adult patients with hypertension and T2DM. Literature search will be conducted in MEDLINE, EMBASE, Scopus, Cochrane and Web of Science databases from anytime until April 2024. Nutritional interventions would have been applied in addition to regular or standard treatment, which is prescribed and/or provided by the healthcare system. Studies in English and Spanish will be selected and reviewed by two independent reviewers. Risk of bias will be assessed using the Cochrane tool for RCTs. Heterogeneity and publication bias will be estimated using the I and Egger's test, respectively.
Ethics approval was not required for this systematic review, considering there was no direct data collection or participation of patients. The investigators will write a manuscript of the final detailed report with the study development and main findings to be published in a peer- reviewed journal. The main findings may be shared with academia partners and groups working on similar topics in LMICs, in addition to policymakers and authorities in these countries.
CRD42023483847.
高血压和 2 型糖尿病（T2DM）是全球两种高发的非传染性疾病，在中低收入国家（LMICs）均导致残疾和过早死亡。针对更健康的饮食模式或食物和营养素摄入的营养干预措施在这种疾病的管理中具有重要作用。本系统评价旨在评估营养干预对 LMIC 中高血压和 T2DM 成年患者血压和血糖管理的影响。
我们将对营养干预对高血压和 T2DM 成年患者血压和血糖影响的随机对照试验（RCTs）进行系统评价。文献检索将在 MEDLINE、EMBASE、Scopus、Cochrane 和 Web of Science 数据库中进行，时间范围为从现在到 2024 年 4 月。营养干预将在常规或标准治疗之外应用，常规或标准治疗是由医疗保健系统规定和/或提供的。将选择并由两名独立评审员审查英语和西班牙语的研究。使用 Cochrane RCT 工具评估偏倚风险。使用 I 检验和 Egger 检验分别估计异质性和发表偏倚。
由于本系统评价没有直接收集数据或患者参与，因此不需要伦理批准。研究人员将撰写一份最终详细报告的手稿，其中包含研究进展和主要发现，将在同行评议的期刊上发表。主要发现可能会与学术界合作伙伴以及在 LMICs 从事类似主题的团体，以及这些国家的政策制定者和当局分享。
PROSPERO 注册号：CRD42023483847。
