[Effect of antenatal ethanol exposures on the function of the hemato-encephalic barrier in animals].

Blood-brain barrier permeability for P32, H3-valine, H3-tyrosine, S35-methionine was investigated in rat offsprings, 20 and 60 days old, that had been antenatally exposed to ethanol. In experimental 20-day-old rat offsprings P32 incorporation in brain structures was lower than in the controls. In mature rats that had been exposed to antenatal ethanol, a different degree decrease in labelled amino acid penetration and alterations in P32 penetration into different brain structures were found. Significant differences in stress-induced changes of blood-brain barrier permeability were observed in experimental and control animals.