Laboratory of Molecular Nutrition, Graduate School of Environmental and Life Science, Kyoto Prefectural University.
J Nutr Sci Vitaminol (Tokyo). 2024;70(5):434-440. doi: 10.3177/jnsv.70.434.
Obesity, a factor increasing the risk of metabolic diseases such as type 2 diabetes, dyslipidemia, and hypertension, can be reduced by the intake of soy isoflavones. In this study, we investigated whether skeletal muscle PGC1α, a transcriptional activator known to promote a variety of exercise-related metabolic processes, is involved in the anti-obesity effects of soy isoflavones using skeletal muscle-specific PGC1α knockout mice. The results showed that the intake of soy isoflavones reduced white adipose tissue weight and increased expression of energy metabolism-related genes such as mitochondrial function, lipolysis, and fatty acid oxidation in skeletal muscle. However, these effects were not observed in skeletal muscle-specific PGC1α knockout mice. In C2C12 myoblasts with overexpressing PGC1α, soy isoflavone treatment increased energy-metabolism related genes. Therefore, PGC1α of skeletal muscle is likely to be involved in the anti-obesity effects of soy isoflavones.
肥胖是 2 型糖尿病、血脂异常和高血压等代谢性疾病的风险因素，而摄入大豆异黄酮可以降低肥胖的风险。在这项研究中，我们使用骨骼肌特异性 PGC1α 敲除小鼠，研究了作为转录激活因子的骨骼肌 PGC1α是否参与了大豆异黄酮的抗肥胖作用，该转录激活因子已知可以促进各种与运动相关的代谢过程。结果表明，摄入大豆异黄酮可减少白色脂肪组织的重量，并增加骨骼肌中与能量代谢相关的基因的表达，如线粒体功能、脂肪分解和脂肪酸氧化。然而，这些作用在骨骼肌特异性 PGC1α 敲除小鼠中没有观察到。在过表达 PGC1α 的 C2C12 成肌细胞中，大豆异黄酮处理增加了与能量代谢相关的基因。因此，骨骼肌中的 PGC1α 可能参与了大豆异黄酮的抗肥胖作用。
