脑线粒体自噬的时空变化
Brain mitophagy in space and time.
作者信息
Nikoletopoulou Vassiliki
机构信息
Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
出版信息
EMBO J. 2024 Dec;43(23):5781-5783. doi: 10.1038/s44318-024-00275-2. Epub 2024 Oct 30.
Abstract
The selective turnover of mitochondria via autophagy, known as mitophagy, is a major quality control mechanism safeguarding eukaryotic cells, including highly specialized neurons in the mammalian brain. A new resource by Rappe et al (2024) now provides a spatiotemporal landscape of mitophagy changes during mouse brain aging at unprecedented resolution, encompassing different cell types and subregions, and revealing unanticipated, context-specific dynamics.
摘要
通过自噬对线粒体进行选择性更新，即线粒体自噬，是保护真核细胞的一种主要质量控制机制，包括哺乳动物大脑中高度特化的神经元。Rappe等人（2024年）的一项新资源现在以前所未有的分辨率提供了小鼠大脑衰老过程中线粒体自噬变化的时空图景，涵盖了不同的细胞类型和亚区域，并揭示了意想不到的、特定背景下的动态变化。
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