Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Department of Oncology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, 519100, China.
Sci Rep. 2024 Oct 30;14(1):26160. doi: 10.1038/s41598-024-77874-w.
Sleep disorders significantly impact the quality of life for many individuals, which remain largely unrecognized. It is widely believed that dietary nutrient intake plays a crucial role in promoting healthy sleep patterns. However, there is lack of research focusing on cancer survivors. This study utilized the National Health and Nutrition Examination Survey (NHANES) database to investigate the correlation between dietary nutrient intake and sleep disorders in cancer survivors. Analyzing data from 2882 cancer survivors in NHANES spanning from 2005 to 2018. Dietary nutrient intake was evaluated through two 24-h dietary recalls. Weighted multivariable logistic regression model was employed to further applied to explore the association between dietary fiber intake and sleep disorders while controlling for relevant confounding factors. Additionally, the nonlinear and dose-response relationships were explored using restricted cubic spline (RCS) regression along with smooth curve fitting and threshold effect analysis. Stratified analysis and interaction analysis were conducted to assess the consistency of the results. Univariable and multivariable analysis demonstrated that dietary fiber intake showed negative correlation with sleep disorders (P < 0.05). Treating dietary fiber intake as continuous variable. After accounting for all covariates, the study reaffirmed the protective role of dietary fiber (odds ratio [OR]: 0.99, 95% confidence interval [CI]: 0.98-0.99, P = 0.044). Analysis of dietary fiber intake in quartiles further supported this trend (P < 0.001). Interestingly, further investigations indicated that dietary fiber intake was not associated with sleep apnea, insomnia, restless legs syndrome, or other types of sleep disorders (P > 0.05). Notably, no statistically significant interactions were observed in all subgroup analyses except poverty income ratio (PIR) (P for interaction < 0.05), indicating that the protective effect of dietary fiber on sleep disorders was more pronounced in individuals with PIR ≥ 2.5. Our results suggest that adequate dietary fiber intake may be beneficial dietary strategy to reduce sleep disorders in cancer survivors.
睡眠障碍会显著影响许多人的生活质量，但这些问题在很大程度上仍未得到认识。人们普遍认为，饮食营养摄入对促进健康的睡眠模式起着至关重要的作用。然而，目前针对癌症幸存者的相关研究还很缺乏。本研究利用国家健康和营养调查（NHANES）数据库，调查了癌症幸存者的饮食营养摄入与睡眠障碍之间的相关性。分析了 NHANES 中 2005 年至 2018 年间 2882 名癌症幸存者的数据。通过两次 24 小时饮食回忆来评估饮食营养摄入。采用加权多变量逻辑回归模型进一步应用于探索膳食纤维摄入与睡眠障碍之间的关联，同时控制相关混杂因素。此外，还使用受限立方样条（RCS）回归以及平滑曲线拟合和阈值效应分析来探索非线性和剂量反应关系。进行分层分析和交互作用分析以评估结果的一致性。单变量和多变量分析表明，膳食纤维摄入与睡眠障碍呈负相关（P<0.05）。将膳食纤维摄入量视为连续变量。在考虑了所有协变量后，该研究再次证实了膳食纤维的保护作用（比值比[OR]：0.99，95%置信区间[CI]：0.98-0.99，P=0.044）。进一步对膳食纤维摄入量进行四分位分析也支持了这一趋势（P<0.001）。有趣的是，进一步的研究表明，膳食纤维摄入与睡眠呼吸暂停、失眠、不宁腿综合征或其他类型的睡眠障碍无关（P>0.05）。值得注意的是，除贫困收入比（PIR）（P<0.05）外，所有亚组分析中均未观察到统计学显著的交互作用，这表明膳食纤维对睡眠障碍的保护作用在 PIR≥2.5 的个体中更为明显。我们的研究结果表明，充足的膳食纤维摄入可能是一种有益的饮食策略，可以减少癌症幸存者的睡眠障碍。
