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睡眠障碍作为重度抑郁症的临床风险因素：与认知障碍相关。

Sleep disorder as a clinical risk factor of major depression: associated with cognitive impairment.

机构信息

Research Center of Biological Psychiatry, Suzhou Guangji Hospital, School of Basic Medicine and Biological Sciences, Suzhou Medical College of Soochow University, Suzhou 215137, Jiangsu Province, PR China.

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu Province, PR China.

出版信息

Asian J Psychiatr. 2022 Oct;76:103228. doi: 10.1016/j.ajp.2022.103228. Epub 2022 Aug 9.

DOI:10.1016/j.ajp.2022.103228
PMID:35973338
Abstract

BACKGROUND

This research aims explored the sleep disorder (SD) role in major depressive disorder (MDD), and the SD influencing their cognition.

METHODS

372 MDD patients and 457 healthy controls (HCs) were enrolled.

RESULTS

Patients increased a 38.88 times SD risk compared with HCs. In patients, visuospatial/constructional score was lower in SD than non-SD, and PSQI score was negatively associated with visuospatial/constructional score of SD. In SD and non-SD, RBANS scores were lower in MDD than HCs, excepted for visuospatial/constructional in non-SD.

CONCLUSION

The SD as a MDD risk factor, has more serious visuospatial/constructional impairment alleviated via improving sleep/depression in patients.

摘要

背景

本研究旨在探讨睡眠障碍（SD）在重度抑郁症（MDD）中的作用，以及 SD 对认知的影响。

方法

纳入 372 例 MDD 患者和 457 例健康对照者（HCs）。

结果

与 HCs 相比，患者发生 SD 的风险增加了 38.88 倍。在患者中，SD 组的视空间/结构评分低于非 SD 组，PSQI 评分与 SD 患者的视空间/结构评分呈负相关。在 SD 和非 SD 患者中，除非 SD 患者的视空间/结构外，RBANS 评分均低于 HCs。

结论

SD 是 MDD 的一个危险因素，在患者中，通过改善睡眠/抑郁，SD 对视空间/结构的损害更为严重。

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