Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
College of Chemical Engineering, Nanjing Forestry University, 210037 Nanjing, China.
J Am Chem Soc. 2024 Nov 13;146(45):30717-30727. doi: 10.1021/jacs.4c12254. Epub 2024 Oct 31.
Although radioactive experiments are necessary in radiopharmaceutical drug discovery and theranostic cancer research, they are expensive, require special facilities, and face certain restrictions. Thus, finding techniques not involving radioactivity is highly beneficial for minimizing these disadvantages in such research. In this regard, methods using inductively coupled plasma-mass spectrometry (ICP-MS) have emerged as viable alternatives to traditional radioactive approaches. Despite its potential, practical applications of ICP-MS in radiopharmaceutical cancer research have only emerged in recent years. This Perspective focuses on the development and implementation of nonradioactive ICP-MS-based assays in radiopharmaceutical research and aims to inspire future research efforts in this area.
尽管放射性实验在放射性药物研发和治疗性癌症研究中是必要的，但它们昂贵、需要特殊设备，并面临一定的限制。因此，寻找不涉及放射性的技术对于最大限度地减少此类研究中的这些缺点非常有益。在这方面，使用电感耦合等离子体质谱（ICP-MS）的方法已经成为传统放射性方法的可行替代品。尽管有这种潜力，但 ICP-MS 在放射性药物癌症研究中的实际应用直到近年来才出现。本观点侧重于开发和实施基于非放射性 ICP-MS 的放射性药物研究中的测定方法，并旨在激发该领域未来的研究工作。
