亚甲基四氢叶酸还原酶 C677T、A1298C 多态性、甲硫氨酸合成酶还原酶 A66G 和甲硫氨酸合成酶 A2756G 多态性与男性不育风险：系统评价和荟萃分析。

MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.

机构信息

Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan Province, 570311, China.

The First Hospital of Shijiazhuang, Shijiazhuang, Heibei Province, 050011, China.

出版信息

Reprod Biol Endocrinol. 2024 Oct 30;22(1):133. doi: 10.1186/s12958-024-01306-7.

DOI:10.1186/s12958-024-01306-7

PMID:39478547

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11523872/

Abstract

BACKGROUND

Epidemiological studies have reported that polymorphisms of folate-metabolizing genes have a significant impact on male infertility. However, the results of published studies have come to different conclusions.

OBJECTIVE

To determine an association between folate-metabolizing gene polymorphisms and the risk of male infertility.

METHODS

The meta-analysis was conducted according to the PRISMA 2020 statement. The protocol was registered with PROSPERO (CRD42023412251). Studies were searched from PubMed, Google Scholar, Embase, Scopus, and the Cochrane Library up to 24st October2023. Articles that satisfied the inclusion criteria were evaluated for their quality using the Newcastle-Ottawa Scale. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Meta-analysis was conducted using STATA 12.

RESULTS

Forty-six case-control studies were included in the meta-analysis which comprised 20,639 participants. The pooled analysis revealed that the MTHFR C677T polymorphism was significantly associated with male infertility and abnormospermia.Three-fifths of the model showed there was a significant association between the MTR A2756G polymorphism and male infertility. Both MTHFR A1298C and MTRR A66G polymorphisms were not significantly associated with male fertility. Furthermore, subgroup analysis revealed a significant association between the MTHFR C677T polymorphism and male fertility in Asian countries.

CONCLUSION

This meta-analysis suggests that the MTHFR C677T and MTR A2756G polymorphisms may be a potential risk factor for male infertility.

摘要

背景

流行病学研究报告称，叶酸代谢基因多态性对男性不育有显著影响。然而，已发表研究的结果得出了不同的结论。

目的

确定叶酸代谢基因多态性与男性不育风险之间的关联。

方法

根据 PRISMA 2020 声明进行荟萃分析。该方案已在 PROSPERO（CRD42023412251）中注册。研究从 PubMed、Google Scholar、Embase、Scopus 和 Cochrane Library 中检索，检索时间截至 2023 年 10 月 24 日。使用纽卡斯尔-渥太华量表评估符合纳入标准的文章的质量。从合格研究中提取数据，并使用 STATA 12 分析汇总优势比（OR）和 95%置信区间（CI）。

结果

荟萃分析纳入了 46 项病例对照研究，共包含 20639 名参与者。汇总分析显示，MTHFR C677T 多态性与男性不育和异常精子症显著相关。五分之三的模型表明，MTR A2756G 多态性与男性不育显著相关。MTHFR A1298C 和 MTRR A66G 多态性与男性生育力无显著相关性。此外，亚组分析显示，MTHFR C677T 多态性与亚洲国家男性生育力之间存在显著关联。