Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan.
Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.
Am J Mens Health. 2023 May-Jun;17(3):15579883231176657. doi: 10.1177/15579883231176657.
The objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant studies. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Review Manager 5.4 was used for statistical analysis. Nineteen case-control studies were included in this meta-analysis which comprised 3621 cases and 3327 controls. Pooled analysis revealed that there is a significant association between MTR A2756G polymorphism with male infertility except for the dominant model. The ORs and 95% CI for each genetic model were as follows: 1.21 [1.03-1.42] for the allele model (G vs. A), 2.31 [1.38-3.96] for the additive model (GG vs. AA), 1.17 [0.98-1.38] for the dominant model (GG+AG vs. AA) and 2.10 [1.55-2.86] for the recessive model (GG vs. AG+AA). MTRR A66G has no noticeable association with male infertility. The current meta-analysis suggests that MTR A2756G polymorphism might be a potential risk factor for male infertility. In the future, the sample size should be increased to confirm the present results.
本研究旨在探讨叶酸基因 MTR A2756G 和 MTRR A66G 多态性与男性不育风险的关联。通过检索 Google Scholar、PubMed 和 Science Direct 数据库，查找相关研究。从合格研究中提取数据，并进行合并优势比（OR）的 95%置信区间（CI）分析。使用 Review Manager 5.4 进行统计分析。本荟萃分析纳入了 19 项病例对照研究，共包括 3621 例病例和 3327 例对照。合并分析显示，MTR A2756G 多态性与男性不育之间存在显著关联，但不包括显性模型。每个遗传模型的 OR 和 95%CI 如下：1. 等位基因模型（G 对 A）为 1.21[1.03-1.42]，2. 加性模型（GG 对 AA）为 2.31[1.38-3.96]，3. 显性模型（GG+AG 对 AA）为 1.17[0.98-1.38]，4. 隐性模型（GG 对 AG+AA）为 2.10[1.55-2.86]。MTRR A66G 与男性不育无明显关联。本荟萃分析提示，MTR A2756G 多态性可能是男性不育的潜在危险因素。未来应增加样本量以验证本研究结果。
