Baggiolini M
Bull Schweiz Akad Med Wiss. 1979 Sep;35(4-6):283-99.
The main source of proteinases that degrade tissue components in the course of inflammation are neutrophil leukocytes and macrophages. Both cells contain and/or produce a large variety of acid and neutral hydrolases including representatives of all four classes of tissue proteinases. Neutrophils are short-lived end cells with large enzyme stores (i.e. azurophil and specific granules) which they normally discharge in the course of phagocytosis. Macrophages are long-lived cells with a great potential for functional differentiation. In macrophages, proteinases and other lytic enzymes are released both by phagocytosis and by secretion (the latter particularly in activated macrophages) and replaced continuously by de novo synthesis. The acid and neutral proteinases of neutrophils and macrophages, their subcellular localization, their properties in relation to tissue damage and the mechanisms of their release are described.
在炎症过程中降解组织成分的蛋白酶的主要来源是中性粒细胞和巨噬细胞。这两种细胞都含有和/或产生多种酸性和中性水解酶，包括所有四类组织蛋白酶的代表。中性粒细胞是寿命短暂的终末细胞，具有大量的酶储存（即嗜天青颗粒和特异性颗粒），它们通常在吞噬过程中释放这些酶。巨噬细胞是寿命长的细胞，具有很大的功能分化潜力。在巨噬细胞中，蛋白酶和其他溶解酶通过吞噬作用和分泌作用（后者尤其在活化的巨噬细胞中）释放，并通过重新合成不断补充。本文描述了中性粒细胞和巨噬细胞的酸性和中性蛋白酶、它们的亚细胞定位、它们与组织损伤相关的特性以及它们的释放机制。
