Sarter Hélène, Crétin Thibaut, Savoye Guillaume, Fumery Mathurin, Leroyer Ariane, Dauchet Luc, Paupard Thierry, Coevoet Hugues, Wils Pauline, Richard Nicolas, Turck Dominique, Ley Delphine, Gower-Rousseau Corinne
CHU Lille, Public Health, Epidemiology and Economic Health Unit, EPIMAD Registry, Maison Régionale de la Recherche Clinique, F-59000 Lille, France.
Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille F-59000, France.
Lancet Reg Health Eur. 2024 Oct 18;47:101097. doi: 10.1016/j.lanepe.2024.101097. eCollection 2024 Dec.
In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period.
Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time.
A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn's disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 10 person-years, respectively. The incidence of CD increased from 5.1/10 in 1988-1990 to 7.9/10 in 2015-2017 (annual percent change (APC): +1.9%, p < 0.0001). The incidence of UC increased from 4.5/10 to 6.1/10 (APC: +1.3%, p < 0.0001). The largest increase was observed in children (+4.3% in CD, p < 0.0001; +5.4% in UC, p < 0.0001) followed by young adults aged 17-39 years (+1.9% in CD, p < 0.0001; +1.5% in UC, p < 0.0001). The increase in UC incidence was significantly higher in women than in men (+1.9% in women, +0.8% in men; p = 0.006). We estimated that in our area, by 2030, nearly 0.6% of the population will have IBD.
The persistent increase of IBD incidence among children and young adults but also in women with UC in Northern France, suggests the persistence of substantial predisposing environmental factors.
Santé Publique France; INSERM; Amiens, Lille and Rouen University Hospitals.
在工业化国家，炎症性肠病（IBD）的发病率似乎已趋于稳定。本研究调查了法国北部30年间IBD的发病率及表型。
纳入1988年至2017年法国北部基于人群的EPIMAD登记系统中记录的所有IBD患者，我们根据年龄、性别和时间描述了IBD的发病率及临床表现。
共记录到22,879例IBD新发病例（克罗恩病（CD）占59%（n = 13,445），溃疡性结肠炎（UC）占38%（n = 8803），未分类IBD（IBDU）占3%（n = 631））。在研究期间，IBD、CD和UC的发病率分别为每10人年12.7例、7.2例和5.1例。CD的发病率从1988 - 1990年的5.1/10增至2015 - 2017年的7.9/10（年变化百分比（APC）：+1.9%，p < 0.0001）。UC的发病率从4.5/10增至6.1/10（APC：+1.3%，p < 0.0001）。儿童中增幅最大（CD中+4.3%，p < 0.0001；UC中+5.4%，p < 0.0001），其次是17 - 39岁的年轻人（CD中+1.9%，p < 0.0001；UC中+1.5%，p < 0.0001）。UC发病率的增幅在女性中显著高于男性（女性为+1.9%，男性为+0.8%；p = 0.006）。我们估计，到2030年，在我们地区近0.6%的人口将患有IBD。
法国北部儿童、年轻人以及患UC的女性中IBD发病率持续上升，提示大量易感环境因素持续存在。
法国公共卫生署；法国国家健康与医学研究院；亚眠、里尔和鲁昂大学医院。
