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新冠疫苗接种后出现的原发性腭部震颤：一例报告

Essential Palatal Tremor Following COVID-19 Vaccine: A Case Report.

作者信息

Toumi Khalil, Naji Yahya, Laadami Sara, Adali Nawal

机构信息

Department of Neurology, CHU (Centre Hospitalier Universitaire) Souss Massa, Agadir, MAR.

Department of Neurology, Agadir University Hospital, Agadir, MAR.

出版信息

Cureus. 2024 Sep 29;16(9):e70420. doi: 10.7759/cureus.70420. eCollection 2024 Sep.

DOI:10.7759/cureus.70420
PMID:39479097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11522943/
Abstract

Palatal tremor (PT) is an infrequent disorder characterized by abnormal movement distinguished into symptomatic palatal tremor (SPT) and essential palatal tremor (EPT). SPT can have various causes, including damage to the Guillain-Mollaret triangle and hypertrophy of the inferior olive. In contrast, EPT is often associated with clicking sounds in the ears with normal imaging results and may have a functional origin. We describe a case of a 20-year-old girl presenting with clinical symptoms of PT two days after receiving the SARS-CoV-2 AstraZeneca vaccine. The patient had persistent audible clicks associated with rhythmic contractions of the soft palate. Complete resolution of symptoms occurred two days after the administration of oral clonazepam. This is the first known case of PT caused by the SARS-CoV-2 AstraZeneca vaccine.

摘要

腭震颤（PT）是一种罕见的疾病，其特征为异常运动，可分为症状性腭震颤（SPT）和原发性腭震颤（EPT）。SPT可有多种病因，包括 Guillain-Mollaret 三角损伤和下橄榄核肥大。相比之下，EPT 常与耳部咔嗒声相关，影像学检查结果正常，可能起源于功能性因素。我们报告一例 20 岁女孩，在接种阿斯利康新冠疫苗两天后出现 PT 的临床症状。患者伴有软腭节律性收缩的持续性可闻及咔嗒声。口服氯硝西泮两天后症状完全缓解。这是已知首例由阿斯利康新冠疫苗引起的 PT 病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e6/11522943/e3a1307df4f9/cureus-0016-00000070420-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e6/11522943/e3a1307df4f9/cureus-0016-00000070420-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e6/11522943/e3a1307df4f9/cureus-0016-00000070420-i01.jpg

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本文引用的文献

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A review of neurological side effects of COVID-19 vaccination.COVID-19 疫苗接种的神经副作用综述。
Eur J Med Res. 2023 Feb 25;28(1):102. doi: 10.1186/s40001-023-00992-0.
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COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series.COVID-19疫苗接种与神经系统表现：病例报告及病例系列综述
Brain Sci. 2022 Mar 18;12(3):407. doi: 10.3390/brainsci12030407.
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Clinical and Imaging Profile of Patients with Palatal Tremor.腭部震颤患者的临床及影像学特征
Mov Disord Clin Pract. 2021 Mar 13;8(3):435-444. doi: 10.1002/mdc3.13173. eCollection 2021 Apr.
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Palatal Tremor - Pathophysiology, Clinical Features, Investigations, Management and Future Challenges.腭震颤 - 病理生理学、临床特征、检查、治疗和未来挑战。
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Palatal Myoclonus (syn. Palatal Tremor).腭肌阵挛（同义词：腭震颤）。
Eur Neurol. 2008;60(6):312-5. doi: 10.1159/000159929. Epub 2008 Oct 3.
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Palatal tremor in childhood: clinical and therapeutic considerations.儿童腭部震颤：临床与治疗考量
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Botulinum toxin is effective and safe for palatal tremor: a report of five cases and a review of the literature.肉毒杆菌毒素治疗腭部震颤有效且安全：5例报告及文献综述
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