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解锁再生密钥：靶向用于骨骼更新的干细胞因子。

Unlocking the regenerative key: Targeting stem cell factors for bone renewal.

作者信息

Karima Gul, Kim Hwan D

机构信息

Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju, Republic of Korea.

Department of IT Convergence (Brain Korea Plus 21), Korea National University of Transportation, Chungju, Republic of Korea.

出版信息

J Tissue Eng. 2024 Oct 27;15:20417314241287491. doi: 10.1177/20417314241287491. eCollection 2024 Jan-Dec.

DOI:10.1177/20417314241287491
PMID:39479284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11523181/
Abstract

Stem cell factors (SCFs) are pivotal factors existing in both soluble and membrane-bound forms, expressed by endothelial cells (ECs) and fibroblasts throughout the body. These factors enhance cell growth, viability, and migration in multipotent cell lineages. The preferential expression of SCF by arteriolar ECs indicates that arterioles create a unique microenvironment tailored to hematopoietic stem cells (HSCs). Insufficiency of SCF within bone marrow (BM)-derived adipose tissue results in decreased their overall cellularity, affecting HSCs and their immediate progenitors critical for generating diverse blood cells and maintaining the hematopoietic microenvironment. SCF deficiency disrupts BM function, impacting the production and differentiation of HSCs. Additionally, deleting SCF from adipocytes reduces lipogenesis, highlighting the crucial role of SCF/c-kit signaling in controlling lipid accumulation. This review elucidates the sources, roles, mechanisms, and molecular strategies of SCF in bone renewal, offering a comprehensive overview of recent advancements, challenges, and future directions for leveraging SCF as a key agent in regenerative medicine.

摘要

干细胞因子（SCFs）是以可溶性和膜结合形式存在的关键因子，由全身的内皮细胞（ECs）和成纤维细胞表达。这些因子可增强多能细胞谱系中的细胞生长、活力和迁移。小动脉内皮细胞对SCF的优先表达表明，小动脉创造了一个专门为造血干细胞（HSCs）量身定制的独特微环境。骨髓（BM）来源的脂肪组织中SCF不足会导致其总体细胞数量减少，影响对产生多种血细胞和维持造血微环境至关重要的造血干细胞及其直接祖细胞。SCF缺乏会破坏骨髓功能，影响造血干细胞的产生和分化。此外，从脂肪细胞中删除SCF会减少脂肪生成，突出了SCF/c-kit信号在控制脂质积累中的关键作用。本综述阐明了SCF在骨更新中的来源、作用、机制和分子策略，全面概述了利用SCF作为再生医学关键因子的最新进展、挑战和未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/87a9cdd9c277/10.1177_20417314241287491-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/6480ffe32d74/10.1177_20417314241287491-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/9d97c993d1b5/10.1177_20417314241287491-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/b59bf1a756d5/10.1177_20417314241287491-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/9497d0691b1f/10.1177_20417314241287491-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/71c556bff154/10.1177_20417314241287491-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/87a9cdd9c277/10.1177_20417314241287491-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/6480ffe32d74/10.1177_20417314241287491-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/9d97c993d1b5/10.1177_20417314241287491-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/b59bf1a756d5/10.1177_20417314241287491-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/9497d0691b1f/10.1177_20417314241287491-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/71c556bff154/10.1177_20417314241287491-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae8/11523181/87a9cdd9c277/10.1177_20417314241287491-fig5.jpg

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