Velazquez Cruz Miriam, Salinas-Arellano Eric, Castro Dionicio Ines, Jeyaraj Jonathan G, Mirtallo Ezzone Nathan P, de Blanco Esperanza J Carcache
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210.
Primary co-authors.
Phytochem Lett. 2024 Jun;61:106-114. doi: 10.1016/j.phytol.2024.04.005. Epub 2024 Apr 12.
The genus has several species, most notably , with reported cytotoxic and venotonic effects. The angiogenic effect from is of interest given the current limitations of anti-angiogenic therapeutics. (Willdenow), known as the Ohio Buckeye Tree is a species native to North America with reported medicinal use by the Native Americans. Previous phytochemical studies have focused on the seed and leaf contents of the species, with most of them reporting cytotoxic activity. In this study, we assessed preliminary anti-angiogenic activity and toxicity of isolated compounds from the bark of utilizing a zebrafish () model. Procyanidin A2 and epicatechin, two pure isolates, were tested using zebrafish and gave an anti-angiogenic response, suggesting an underlying mechanism involved in vascular development.
该属有几个物种，最显著的是 ，有细胞毒性和静脉张力作用的报道。鉴于抗血管生成疗法目前的局限性， 的血管生成作用备受关注。（威尔登诺），即俄亥俄七叶树，是一种原产于北美的物种，据报道美洲原住民曾将其用于药用。先前的植物化学研究集中在该物种的种子和叶子成分上，其中大多数报道了细胞毒性活性。在本研究中，我们利用斑马鱼（ ）模型评估了从 树皮中分离出的化合物的初步抗血管生成活性和毒性。原花青素A2和表儿茶素这两种纯分离物，在斑马鱼实验中表现出抗血管生成反应，提示其参与血管发育的潜在机制。
